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lasp1 LIM and SH3 protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 323216, updated on 12-Sep-2024

Summary

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Official Symbol
lasp1provided by ZNC
Official Full Name
LIM and SH3 protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1936
See related
Ensembl:ENSDARG00000057867 AllianceGenome:ZFIN:ZDB-GENE-030131-1936
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb92f05; zgc:77542; wu:fb92f05
Summary
Predicted to enable actin filament binding activity. Predicted to act upstream of or within ion transport. Predicted to be located in cell cortex and cytoskeleton. Predicted to be active in focal adhesion. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (16072972..16109815, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15923172..15960015, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:dkey-81l17.6 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene transfer RNA cysteine (anticodon GCA)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish. Grossi I, et al. Genes (Basel), 2022 Dec 22. PMID 36672776, Free PMC Article
  2. The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis. Yan Y, et al. Atherosclerosis, 2019 Jan. PMID 30500605
  3. Efficient disruption of Zebrafish genes using a Gal4-containing gene trap. Balciuniene J, et al. BMC Genomics, 2013 Sep 14. PMID 24034702, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish.
    Title: Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LIM and SH3 domain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212636.1 → NP_997801.1  LIM and SH3 domain protein 1

    See identical proteins and their annotated locations for NP_997801.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066574
    UniProtKB/TrEMBL
    A9JT31, F6P5I6, Q6NYJ1
    Related
    ENSDARP00000051806.4, ENSDART00000051807.6
    Conserved Domains (3) summary
    smart00227
    Location:98 → 128
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11934
    Location:176 → 234
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    16072972..16109815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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