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mat2aa methionine adenosyltransferase 2Aa [ Danio rerio (zebrafish) ]

Gene ID: 323329, updated on 5-Jan-2025

Summary

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Official Symbol
mat2aaprovided by ZNC
Official Full Name
methionine adenosyltransferase 2Aaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2049
See related
Ensembl:ENSDARG00000040334 AllianceGenome:ZFIN:ZDB-GENE-030131-2049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mat2a; fd12a12; wu:fb95e01; wu:fd12a12; si:ch73-340n8.1
Summary
Predicted to enable methionine adenosyltransferase activity. Acts upstream of or within cardiac muscle cell development. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Is expressed in anterior neural tube; epiphysis; heart; optic cup; and somite. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mat2aa in Genome Data Viewer
Location:
chromosome: 10
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (7809019..7821687, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (7850319..7862987, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene surfactant protein Ba Neighboring gene lysyl oxidase a Neighboring gene myeloid-specific peroxidase Neighboring gene phosphatidylinositol 4,5-bisphosphate 5-phosphatase A Neighboring gene uncharacterized LOC137490364 Neighboring gene smoothelin a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. MAT2A mutations predispose individuals to thoracic aortic aneurysms. Guo DC, et al. Am J Hum Genet, 2015 Jan 8. PMID 25557781, Free PMC Article
  2. Embryo Microinjection of Selenomethionine Reduces Hatchability and Modifies Oxidant Responsive Gene Expression in Zebrafish. Thomas JK, et al. Sci Rep, 2016 May 23. PMID 27210033, Free PMC Article
  3. Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening. Ding Y, et al. Circ Res, 2013 Feb 15. PMID 23283723, Free PMC Article
  4. Disruption of the folate pathway in zebrafish causes developmental defects. Lee MS, et al. BMC Dev Biol, 2012 Apr 5. PMID 22480165, Free PMC Article
  5. Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Lawir DF, et al. Commun Biol, 2024 Jan 5. PMID 38182651, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methionine adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine adenosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within circulatory system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of methionine adenosyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methionine adenosyltransferase II, alpha a
NP_001277009.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290080.1 → NP_001277009.1  methionine adenosyltransferase II, alpha a

    See identical proteins and their annotated locations for NP_001277009.1

    Status: VALIDATED

    Source sequence(s)
    CU681843
    UniProtKB/TrEMBL
    F1QYU7, H9MZH3
    Related
    ENSDARP00000105782.2, ENSDART00000121531.3
    Conserved Domains (4) summary
    PTZ00104
    Location:18 → 395
    PTZ00104; S-adenosylmethionine synthase; Provisional
    pfam00438
    Location:18 → 114
    S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
    pfam02772
    Location:129 → 250
    S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
    pfam02773
    Location:252 → 388
    S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    7809019..7821687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212637.1: Suppressed sequence

    Description
    NM_212637.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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