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drg2 developmentally regulated GTP binding protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 323355, updated on 9-Dec-2024

Summary

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Official Symbol
drg2provided by ZNC
Official Full Name
developmentally regulated GTP binding protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040808-29
See related
Ensembl:ENSDARG00000006642 AllianceGenome:ZFIN:ZDB-GENE-040808-29
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb96a09; wu:fb96b01; zgc:101029
Summary
Predicted to enable GTP binding activity. Predicted to be involved in cytoplasmic translation. Predicted to be active in cytoplasm. Orthologous to human DRG2 (developmentally regulated GTP binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See drg2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (40153819..40162867, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (40011961..40021009, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene LLGL scribble cell polarity complex component 1 Neighboring gene myosin XVAa Neighboring gene synaptogyrin 3a Neighboring gene growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression of two closely related GTP-binding proteins from zebrafish. Wei D, et al. DNA Seq, 2004 Aug. PMID 15620211
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC101029

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
developmentally-regulated GTP-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212638.1 → NP_997803.1  developmentally-regulated GTP-binding protein 2

    See identical proteins and their annotated locations for NP_997803.1

    Status: PROVISIONAL

    Source sequence(s)
    AY398336
    UniProtKB/TrEMBL
    Q6AXJ4, Q6TH20
    Related
    ENSDARP00000008399.5, ENSDART00000025285.7
    Conserved Domains (4) summary
    cd01666
    Location:289 → 363
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:63 → 295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1 → 364
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl21455
    Location:3 → 119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    40153819..40162867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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