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coro2aa coronin 2Aa [ Danio rerio (zebrafish) ]

Gene ID: 323538, updated on 2-Nov-2024

Summary

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Official Symbol
coro2aaprovided by ZNC
Official Full Name
coronin 2Aaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2258
See related
Ensembl:ENSDARG00000005210 AllianceGenome:ZFIN:ZDB-GENE-030131-2258
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
coro2a; zgc:73379; wu:fc02b08
Summary
Predicted to enable actin filament binding activity. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; ectoderm; endoderm; neural plate; and presumptive ectoderm. Orthologous to human CORO2A (coronin 2A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See coro2aa in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26605228..26654311)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (25911277..25960603)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495210 Neighboring gene uncharacterized LOC137494821 Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, member B Neighboring gene hemogen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Divergent Hemogen genes of teleosts and mammals share conserved roles in erythropoiesis: analysis using transgenic and mutant zebrafish. Peters MJ, et al. Biol Open, 2018 Aug 28. PMID 30097520, Free PMC Article
  2. Evolutionary and functional diversity of coronin proteins. Xavier CP, et al. Subcell Biochem, 2008. PMID 18925374
  3. Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. Sanchez NE, et al. G3 (Bethesda), 2017 Oct 5. PMID 28855284, Free PMC Article
  4. Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. Pinto RA, et al. BMC Dev Biol, 2018 Jun 19. PMID 29914374, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
coronin-2A
Names
coronin, actin binding protein, 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199643.2 → NP_955937.1  coronin-2A

    See identical proteins and their annotated locations for NP_955937.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060941
    UniProtKB/TrEMBL
    Q6P935
    Related
    ENSDARP00000137370.2, ENSDART00000158193.2
    Conserved Domains (5) summary
    PTZ00421
    Location:10 → 521
    PTZ00421; coronin; Provisional
    pfam08953
    Location:8 → 65
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:350 → 392
    WD40_4; Type of WD40 repeat
    sd00039
    Location:41 → 80
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 316
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    26605228..26654311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159876.5 → XP_005159933.1  coronin-2A isoform X2

    UniProtKB/TrEMBL
    A0A8M2B6N4, F1QR96
    Related
    ENSDARP00000014182.8, ENSDART00000011645.11
    Conserved Domains (5) summary
    PTZ00421
    Location:15 → 526
    PTZ00421; coronin; Provisional
    pfam08953
    Location:13 → 70
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:355 → 397
    WD40_4; Type of WD40 repeat
    sd00039
    Location:46 → 85
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:83 → 321
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_005159877.5 → XP_005159934.1  coronin-2A isoform X1

    UniProtKB/TrEMBL
    A0A0R4IRX7, A0A8M2B6I8
    Related
    ENSDARP00000144803.1, ENSDART00000182040.1
    Conserved Domains (5) summary
    PTZ00421
    Location:10 → 521
    PTZ00421; coronin; Provisional
    pfam08953
    Location:8 → 65
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:350 → 392
    WD40_4; Type of WD40 repeat
    sd00039
    Location:41 → 80
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 316
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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