dvl2 dishevelled segment polarity protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dvl2provided by ZNC
Official Full Name: dishevelled segment polarity protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-041118-20
See related: Ensembl:ENSDARG00000056184 AllianceGenome:ZFIN:ZDB-GENE-041118-20
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu471; zgc:55372; wu:fc05d12; wu:fo71e09; wu:fp54a02
Summary: Predicted to enable frizzled binding activity. Involved in convergent extension; non-canonical Wnt signaling pathway; and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Acts upstream of or within cell migration in hindbrain; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Located in cell cortex and spindle. Is expressed in liver and vertebral column. Orthologous to human DVL2 (dishevelled segment polarity protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (20260449..20293450)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (20008481..20041482)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models.
Title: A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models.
Maternal transcripts for dvl2 and dvl3a are most abundantly expressed, whereas the transcript levels of other dvl genes are negligible. Dvl2 and Dvl3a products are required for the activation of zygotic Wnt/ss-catenin signaling and Wnt/planar cell polarity pathway, and regulate zygotic developmental processes in a dosage-dependent manner.
Title: Mutational analysis of dishevelled genes in zebrafish reveals distinct functions in embryonic patterning and gastrulation cell movements.
Dishevelled interacts with Lurap1 to regulate cellular polarisation during gastrulation.
Title: Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish.
demonstrate that during early zebrafish development Nkd1 does not alter either endogenous or exogenous levels of Dvl2
Title: Dishevelled2 is a stable protein during early zebrafish development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration in hindbrain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in convergent extension	IMP Inferred from Mutant Phenotype more info
involved_in convergent extension	TAS Traceable Author Statement more info
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within head development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within head development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: segment polarity protein dishevelled homolog DVL-2

Names: dishevelled 2, dsh homolog; dishevelled, dsh homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212648.1 → NP_997813.1 segment polarity protein dishevelled homolog DVL-2

See identical proteins and their annotated locations for NP_997813.1

Status: PROVISIONAL

Source sequence(s)

BC044381

UniProtKB/TrEMBL

Q803Q5

Related

ENSDARP00000021237.8, ENSDART00000012450.11

Conserved Domains (5) summary

smart00021
Location:1 → 82

DAX; Domain present in Dishevelled and axin

cd00992
Location:251 → 338

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:408 → 491

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:112 → 249

Dishevelled; Dishevelled specific domain

pfam12316
Location:498 → 737

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal