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selenou1a selenoprotein U 1a [ Danio rerio (zebrafish) ]

Gene ID: 323739, updated on 4-Jan-2025

Summary

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Official Symbol
selenou1aprovided by ZNC
Official Full Name
selenoprotein U 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2459
See related
Ensembl:ENSDARG00000057378 AllianceGenome:ZFIN:ZDB-GENE-030131-2459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
selu; sepu; selu1; prxl2a; fam213a; fc08d10; selenou; fam213aa; zgc:73311; wu:fb06a02; wu:fc08d10
Summary
The protein encoded by this gene belongs to a subfamily of FAM213A/selenoprotein U (SelU), within a peroxiredoxin-like FAM213 superfamily. SelU is unusual in that it has restricted phylogenetic distribution in vertebrates, such as in chicken and fish. Other vertebrate members of this family, including mammals, contain cysteine-containing homologues. SelU proteins contain UxxC (U for selenocysteine and C for cysteine) motif in place of the catalytic CxxC motif found in cysteine-containing homologues. The latter function as redox regulatory proteins, suggesting a similar role for SelU proteins. Like majority of selenoproteins, SelU contains a single selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A paralog of this gene exists on chromosome 12 (GeneID:767744). [provided by RefSeq, Aug 2017]
Orthologs
human mouse all
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Genomic context

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See selenou1a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (18659346..18669575)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (18528354..18538583)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene sideroflexin 3 Neighboring gene PDZ domain containing 7a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular Genetic Anatomy and Risk Profile of Hirschsprung's Disease. Tilghman JM, et al. N Engl J Med, 2019 Apr 11. PMID 30970187, Free PMC Article
  2. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. Castellano S, et al. EMBO Rep, 2004 Jan. PMID 14710190, Free PMC Article
  3. Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury. Penglase S, et al. Free Radic Biol Med, 2014 Oct. PMID 25064324
  4. Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Doretto LB, et al. Cells, 2022 Apr 11. PMID 35455974, Free PMC Article
  5. Composition and evolution of the vertebrate and mammalian selenoproteomes. Mariotti M, et al. PLoS One, 2012. PMID 22479358, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables antioxidant activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
selenoprotein U 1a
Names
UPF0765 protein C10orf58 homolog
family with sequence similarity 213, member A
family with sequence similarity 213, member Aa
peroxiredoxin-like 2 activated in M-CSF stimulated monocytes homolog
peroxiredoxin-like 2A
redox-regulatory protein FAM213A
redox-regulatory protein PAMM homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193525.1 → NP_001180454.1  selenoprotein U 1a

    See identical proteins and their annotated locations for NP_001180454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-3 encode the same selenoprotein.
    Source sequence(s)
    BC154572, CK690434
    UniProtKB/Swiss-Prot
    Q6PBP3
    Related
    ENSDARP00000115912.1, ENSDART00000147905.3
    Conserved Domains (1) summary
    cd02970
    Location:37 → 190
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  2. NM_001354552.1 → NP_001341481.1  selenoprotein U 1a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon in the 5' region compared to variant 1. Variants 1-3 encode the same selenoprotein.
    Source sequence(s)
    CR932438
    UniProtKB/Swiss-Prot
    Q6PBP3
    Related
    ENSDARP00000149078.1, ENSDART00000188249.1
    Conserved Domains (1) summary
    cd02970
    Location:37 → 190
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  3. NM_001354553.1 → NP_001341482.1  selenoprotein U 1a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and an additional exon in the 5' region compared to variant 1. Variants 1-3 encode the same selenoprotein.
    Source sequence(s)
    CR932438
    UniProtKB/Swiss-Prot
    Q6PBP3
    Conserved Domains (1) summary
    cd02970
    Location:37 → 190
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    18659346..18669575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394876.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    285875..296104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200036.1: Suppressed sequence

    Description
    NM_200036.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  2. NR_027705.1: Suppressed sequence

    Description
    NR_027705.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PBP3.2 GenPept UniProtKB/Swiss-Prot:Q6PBP3

Gene LinkOut

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