cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp3c1provided by ZNC
Official Full Name: cytochrome P450, family 3, subfamily c, polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3060
See related: Ensembl:ENSDARG00000015575 AllianceGenome:ZFIN:ZDB-GENE-030131-3060
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CYP3A; zgc:56626; wu:fa96d12; wu:fc26b04
Summary: Enables heme binding activity. Predicted to be located in membrane. Is expressed in several structures, including digestive system; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (40969242..40976532, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (40827384..40834674, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

similar pattern of mRNA expression of Pregnane X Receptor (PXR), CYP3A and multiple drug resistance 1 genes found in fish treated with different PXR inducers suggests that the intrinsic association between these three genes is conserved in zebrafish
Title: Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish.
We report a new cytochrome P450 (CYP) subfamily CYP3C and the cloning through PCR from zebrafish (Danio rerio) of the first member, CYP3C1.
Title: CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio).

Submit: New GeneRIF Correction

General gene information

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Markers

fa96d12.x1 (e-PCR)
- UniSTS:189723

fa96d12.x1 (e-PCR)
- UniSTS:189724

AI722355 (e-PCR)
- UniSTS:206013

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables steroid hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450, family 3, subfamily c, polypeptide 1

Names: cytochrome P450 3C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.