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atxn2l ataxin 2-like [ Danio rerio (zebrafish) ]

Gene ID: 324525, updated on 9-Dec-2024

Summary

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Official Symbol
atxn2lprovided by ZNC
Official Full Name
ataxin 2-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3246
See related
Ensembl:ENSDARG00000011597 AllianceGenome:ZFIN:ZDB-GENE-030131-3246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66471; wu:fc31f08; wu:fi19h05
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in stress granule assembly. Predicted to be active in cytoplasmic stress granule. Orthologous to human ATXN2L (ataxin 2 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See atxn2l in Genome Data Viewer
Location:
chromosome: 3
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (15394407..15425689)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15244595..15275840)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, beta, like Neighboring gene SH2B adaptor protein 1 Neighboring gene si:dkey-56d12.4 Neighboring gene linker for activation of T cells Neighboring gene SPNS lysolipid transporter 1, lysophospholipid

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy. Ding Y, et al. Dis Model Mech, 2023 May 1. PMID 35481478, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ataxin-2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212684.2 → NP_997849.2  ataxin-2-like protein

    Status: VALIDATED

    Source sequence(s)
    BX784026
    UniProtKB/TrEMBL
    A0A8M2BAY3, F1QA42, Q6PFI6
    Related
    ENSDARP00000115477.1, ENSDART00000133168.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    15394407..15425689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009299272.4 → XP_009297547.1  ataxin-2-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8M3AQQ2, Q6PFI6
    Conserved Domains (2) summary
    pfam06741
    Location:213 → 275
    LsmAD; LsmAD domain
    pfam14438
    Location:63 → 142
    SM-ATX; Ataxin 2 SM domain

  2. XM_005163800.5 → XP_005163857.1  ataxin-2-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8M2BBA5, Q6PFI6
    Conserved Domains (2) summary
    pfam06741
    Location:179 → 241
    LsmAD; LsmAD domain
    pfam14438
    Location:29 → 108
    SM-ATX; Ataxin 2 SM domain

  3. XM_068215868.1 → XP_068071969.1  ataxin-2-like protein isoform X3

    UniProtKB/TrEMBL
    Q6PFI6

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394524.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    48394..79583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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