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fbxl14b F-box and leucine-rich repeat protein 14b [ Danio rerio (zebrafish) ]

Gene ID: 324835, updated on 2-Nov-2024

Summary

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Official Symbol
fbxl14bprovided by ZNC
Official Full Name
F-box and leucine-rich repeat protein 14bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3556
See related
Ensembl:ENSDARG00000045801 AllianceGenome:ZFIN:ZDB-GENE-030131-3556
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ppab; fbxl14; wu:fc44g06
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein ubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in hindbrain and midbrain. Orthologous to human FBXL14 (F-box and leucine rich repeat protein 14). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See fbxl14b in Genome Data Viewer
Location:
chromosome: 4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (8610170..8611634, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (8609254..8610718, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 1b Neighboring gene ninjurin 2 Neighboring gene ELKS/RAB6-interacting/CAST family member 1b Neighboring gene wingless-type MMTV integration site family, member 5b Neighboring gene uncharacterized LOC110437837 Neighboring gene uncharacterized LOC110439347 Neighboring gene adiponectin receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential response of multiple zebrafish hepatic F-box protein genes to 17alpha-ethinylestradiol treatment. Zheng H, et al. J Environ Sci (China), 2011. PMID 21793410
  2. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951
  3. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
F-box/LRR-repeat protein 14b
Names
partner of paired b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015043.2 → NP_001015043.1  F-box/LRR-repeat protein 14b

    See identical proteins and their annotated locations for NP_001015043.1

    Status: PROVISIONAL

    Source sequence(s)
    BC163002
    UniProtKB/TrEMBL
    B3DI53, Q5RH13
    Related
    ENSDARP00000067321.3, ENSDART00000067322.5
    Conserved Domains (3) summary
    cd09293
    Location:90 → 296
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:92 → 118
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:5 → 46
    F-box-like

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    8610170..8611634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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