atp6v0cb ATPase H+ transporting V0 subunit cb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp6v0cbprovided by ZNC
Official Full Name: ATPase H+ transporting V0 subunit cbprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4127
See related: Ensembl:ENSDARG00000036577 AllianceGenome:ZFIN:ZDB-GENE-030131-4127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77708; wu:fc74d11; zgc:111904
Summary: Enables voltage-gated calcium channel activity. Predicted to act upstream of or within proton transmembrane transport. Located in presynaptic active zone and synaptic vesicle. Is expressed in head; nervous system; and neural tube. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (39158283..39175750)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (39266296..39283763)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study revealed atp6v0c2 is expressed in a subset of CNS neurons beginning several hours after emergence of post-mitotic neuron; ATP6V0C2 protein is co-localized with presynaptic vesicle marker, SV2
Title: Neuron-specific expression of atp6v0c2 in zebrafish CNS.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of proton-transporting two-sector ATPase complex, proton-transporting domain	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATPase H+ transporting V0 subunit cb

Names: ATPase, H+ transporting, lysosomal, V0 subunit c, b; ATPase, H+ transporting, lysosomal, V0 subunit cb

NP_991117.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205554.1 → NP_991117.1 ATPase H+ transporting V0 subunit cb

See identical proteins and their annotated locations for NP_991117.1

Status: PROVISIONAL

Source sequence(s)

BC065849

UniProtKB/TrEMBL

Q567L6, Q6P041

Related

ENSDARP00000053138.5, ENSDART00000053139.7

Conserved Domains (2) summary

TIGR01100
Location:11 → 116

V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit

cd18176
Location:84 → 151

ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins