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kif20a kinesin family member 20A [ Danio rerio (zebrafish) ]

Gene ID: 325449, updated on 4-Jan-2025

Summary

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Official Symbol
kif20aprovided by ZNC
Official Full Name
kinesin family member 20Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-252
See related
Ensembl:ENSDARG00000044491 AllianceGenome:ZFIN:ZDB-GENE-050522-252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fi34h02; wu:fj10c11; zgc:112061
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within heart development. Predicted to be located in cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule; and nucleus. Human ortholog(s) of this gene implicated in restrictive cardiomyopathy. Orthologous to human KIF20A (kinesin family member 20A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See kif20a in Genome Data Viewer
Location:
chromosome: 21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (34879268..34926619, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (34844778..34892129, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 55 Neighboring gene zgc:56585 Neighboring gene CDC23 (cell division cycle 23, yeast, homolog) Neighboring gene si:dkey-71d15.2 Neighboring gene lipase, member Ia

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings. Louw JJ, et al. PLoS Genet, 2018 Jan. PMID 29357359, Free PMC Article
  2. Metallothionein gene expression in zebrafish embryo-larvae and ZFL cell-line exposed to heavy metal ions. Chan KM, et al. Mar Environ Res, 2006 Jul. PMID 16690118
  3. Expression of mt2 and smt-B upon cadmium exposure and cold shock in zebrafish (Danio rerio). Wu SM, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2008 Aug. PMID 18579444
  4. Cloning of zebrafish metallothionein gene and characterization of its gene promoter region in HepG2 cell line. Yan CH, et al. Biochim Biophys Acta, 2004 Jul 13. PMID 15245916
  5. Dietary iron alters waterborne copper-induced gene expression in soft water acclimated zebrafish (Danio rerio). Craig PM, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Feb. PMID 18987288

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report expression of mt2 and smt-B upon cadmium exposure and cold shock in zebrafish (Danio rerio).
    Title: Expression of mt2 and smt-B upon cadmium exposure and cold shock in zebrafish (Danio rerio).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112061

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF20A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161470.1 → NP_001154942.1  kinesin-like protein KIF20A

    Status: VALIDATED

    Source sequence(s)
    BC095661, BX957298
    UniProtKB/TrEMBL
    A0A8M1NT09, F1QDF0, Q502K6
    Related
    ENSDARP00000065336.4, ENSDART00000065337.5
    Conserved Domains (3) summary
    cl22853
    Location:77 → 510
    Motor_domain; Myosin and Kinesin motor domain
    pfam00225
    Location:84 → 510
    Kinesin; Kinesin motor domain
    pfam07851
    Location:572 → 661
    TMPIT; TMPIT-like protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    34879268..34926619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215787.1 → XP_068071888.1  kinesin-like protein KIF20A isoform X1

    UniProtKB/TrEMBL
    Q502K6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194273.1: Suppressed sequence

    Description
    NM_194273.1: This RefSeq was permanently suppressed because it is based on a chimeric sequence.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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