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twf1a twinfilin actin-binding protein 1a [ Danio rerio (zebrafish) ]

Gene ID: 325677, updated on 2-Nov-2024

Summary

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Official Symbol
twf1aprovided by ZNC
Official Full Name
twinfilin actin-binding protein 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4402
See related
AllianceGenome:ZFIN:ZDB-GENE-030131-4402
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ptk9; twf1; zgc:65922; wu:fd02b03
Summary
Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in actin filament depolymerization; negative regulation of actin filament polymerization; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within negative regulation of actin filament polymerization. Predicted to be located in cytoskeleton. Predicted to be active in actin filament and myofibril. Orthologous to human TWF1 (twinfilin actin binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See twf1a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (753331..765312)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336182.2 (47..678)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336668.1 (8475..12230)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489307 Neighboring gene uncharacterized LOC137489308 Neighboring gene transmembrane protein 117 Neighboring gene interleukin-1 receptor-associated kinase 4 Neighboring gene GRAM domain-containing protein 2A Neighboring gene uncharacterized LOC101886811

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gene-breaking transposon mutagenesis reveals an essential role for histone H2afza in zebrafish larval development. Sivasubbu S, et al. Mech Dev, 2006 Jul. PMID 16859902
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
twinfilin-1a
Names
PTK9 protein tyrosine kinase 9
twinfilin, actin-binding protein, homolog 1
twinfilin, actin-binding protein, homolog 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199725.1 → NP_956019.1  twinfilin-1a

    See identical proteins and their annotated locations for NP_956019.1

    Status: PROVISIONAL

    Source sequence(s)
    BC058050
    UniProtKB/TrEMBL
    Q6PEI5
    Conserved Domains (2) summary
    cd11284
    Location:176 → 311
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4 → 142
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    753331..765312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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