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slc6a19b solute carrier family 6 member 19b [ Danio rerio (zebrafish) ]

Gene ID: 326030, updated on 2-Nov-2024

Summary

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Official Symbol
slc6a19bprovided by ZNC
Official Full Name
solute carrier family 6 member 19bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4755
See related
Ensembl:ENSDARG00000056719 AllianceGenome:ZFIN:ZDB-GENE-030131-4755
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
slc6a19; zgc:66050; wu:fd58f10
Summary
Predicted to enable neutral L-amino acid transmembrane transporter activity. Predicted to be involved in neutral amino acid transport and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in apical plasma membrane and brush border membrane. Is expressed in floor plate; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Hartnup disease. Orthologous to human SLC6A19 (solute carrier family 6 member 19). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See slc6a19b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (18974074..18998549)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (19168435..19192910)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene retinoid x receptor, beta b Neighboring gene formin homology 2 domain containing 3b Neighboring gene si:ch211-254p10.2 Neighboring gene uncharacterized LOC137487840

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. Buglo E, et al. PLoS One, 2020. PMID 32208444, Free PMC Article
  2. Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model. Cahill T, et al. Cells, 2021 Apr 14. PMID 33920039, Free PMC Article
  3. Ustilaginoidin D induces hepatotoxicity and behaviour aberrations in zebrafish larvae. Wang B, et al. Toxicology, 2021 May 30. PMID 33872729
  4. Excessive selenium affects neural development and locomotor behavior of zebrafish embryos. Zhao G, et al. Ecotoxicol Environ Saf, 2022 Jun 15. PMID 35526456
  5. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Barat A, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Oct. PMID 27287540

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neutral amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 6 member 19b
Names
solute carrier family 6 (neurotransmitter transporter), member 19
solute carrier family 6 (neurotransmitter transporter), member 19b
solute carrier family 6 (neutral amino acid transporter), member 19b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199736.1 → NP_956030.1  solute carrier family 6 member 19b

    See identical proteins and their annotated locations for NP_956030.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059804
    UniProtKB/TrEMBL
    A0A8M1PFT7, Q6PBA3
    Related
    ENSDARP00000073704.5, ENSDART00000079248.6
    Conserved Domains (1) summary
    cd11516
    Location:33 → 613
    SLC6sbd_B0AT1; Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    18974074..18998549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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