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Atox1 Antioxidant 1 copper chaperone [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326216, updated on 18-Sep-2024

Summary

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Official Symbol
Atox1provided by FlyBase
Official Full Name
Antioxidant 1 copper chaperoneprovided by FlyBase
Primary source
FLYBASE:FBgn0052446
Locus tag
Dmel_CG32446
See related
AllianceGenome:FB:FBgn0052446
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12562; CG32446; DmAtox1; Dmel\CG32446
Summary
Predicted to enable copper chaperone activity. Involved in copper ion homeostasis. Predicted to be active in cytosol. Is expressed in embryonic/larval crystal cell; organism; and procrystal cell. Orthologous to human ATOX1 (antioxidant 1 copper chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Atox1 in Genome Data Viewer
Location:
78E2-78E2; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21640995..21642599)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21634095..21635699)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45955 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45956 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin. Theotoki EI, et al. Biol Open, 2019 Oct 15. PMID 31575544, Free PMC Article
  2. Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila. Hua H, et al. Biometals, 2011 Jun. PMID 21465178
  3. Control of Alzheimer's amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila. Sanokawa-Akakura R, et al. PLoS One, 2010 Jan 13. PMID 20084280, Free PMC Article
  4. Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7. Norgate M, et al. Mol Biol Cell, 2006 Jan. PMID 16251357, Free PMC Article
  5. What can flies tell us about copper homeostasis? Southon A, et al. Metallomics, 2013 Oct. PMID 23903872

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results clearly reveal a distorted copper homeostasis in Atox1-deficient Drosophila
    Title: Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables copper chaperone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in copper ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
antioxidant 1 copper chaperone
Names
Atox1-PA
Atox1-PB
CG32446-PA
CG32446-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21640995..21642599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168932.2 → NP_730672.1  antioxidant 1 copper chaperone, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730672.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RR1
    Related
    FBpp0078080
    Conserved Domains (1) summary
    cd00371
    Location:5 → 62
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

  2. NM_001275255.1 → NP_001262184.1  antioxidant 1 copper chaperone, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262184.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PD88
    Conserved Domains (1) summary
    cd00371
    Location:5 → 62
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PD88 M9PD88
Q95RR1 Q95RR1

Gene LinkOut

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