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goe gone early [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32660, updated on 4-Jan-2025

Summary

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Official Symbol
goeprovided by FlyBase
Official Full Name
gone earlyprovided by FlyBase
Primary source
FLYBASE:FBgn0027528
Locus tag
Dmel_CG9634
See related
AllianceGenome:FB:FBgn0027528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD21405; CG9634; Dmel\CG9634; Nepl2
Summary
Involved in negative regulation of stem cell differentiation and oogenesis. Located in plasma membrane. Is expressed in several structures, including adult head; mesectoderm; mesectoderm anlage; midline primordium; and unpaired neurons. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See goe in Genome Data Viewer
Location:
15A3-15A5; 1-55 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16727304..16751910, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16621337..16645943, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TweedleX Neighboring gene TweedleY Neighboring gene TweedleZ Neighboring gene Tweedlealpha Neighboring gene uncharacterized protein Neighboring gene inflated Neighboring gene mitochondrial ribosomal protein L22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. Matsuoka S, et al. PLoS One, 2014. PMID 25420147, Free PMC Article
  2. Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase function. Coates D, et al. Biochem Soc Trans, 2000. PMID 10961941
  3. Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversion. Kamemura K, et al. Nat Commun, 2024 Oct 10. PMID 39389966, Free PMC Article
  4. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
  5. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that a germline factor, Gone early (Goe, CG9634) limits the fraction of primordial germ cells (PGCs) that initiate gametogenesis.
    Title: gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gone early
Names
CG9634-PA
CG9634-PB
CG9634-PC
Neprilysin-like 2
goe-PA
goe-PB
goe-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16727304..16751910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298420.1 → NP_001285349.1  gone early, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285349.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JFT2
    Conserved Domains (1) summary
    cl14813
    Location:179 → 689
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  2. NM_132932.3 → NP_573160.1  gone early, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573160.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XZ14
    Related
    FBpp0074133
    Conserved Domains (1) summary
    cl14813
    Location:184 → 694
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  3. NM_001298421.1 → NP_001285350.1  gone early, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285350.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XZ14
    Conserved Domains (1) summary
    cl14813
    Location:184 → 694
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XZ14.1 Q9XZ14
X2JFT2 X2JFT2

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