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mynn myoneurin [ Danio rerio (zebrafish) ]

Gene ID: 327167, updated on 14-Nov-2024

Summary

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Official Symbol
mynnprovided by ZNC
Official Full Name
myoneurinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5378
See related
Ensembl:ENSDARG00000007271 AllianceGenome:ZFIN:ZDB-GENE-030131-5378
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55724; wu:fd15c04
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cartilage development and regulation of BMP signaling pathway. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in central nervous system; heart; pectoral fin; and pharyngeal arch. Orthologous to human MYNN (myoneurin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See mynn in Genome Data Viewer
Location:
chromosome: 24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (26328782..26343902)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (26183743..26198916)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489250 Neighboring gene apolipoprotein Db Neighboring gene leucine rich repeat containing 34 Neighboring gene si:ch211-230g15.5 Neighboring gene leucine rich repeat containing 31 Neighboring gene SKI-like proto-oncogene b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding. Yang S, et al. iScience, 2022 Jun 17. PMID 35712083, Free PMC Article
  2. Autophagy is essential for cardiac morphogenesis during vertebrate development. Lee E, et al. Autophagy, 2014 Apr. PMID 24441423, Free PMC Article
  3. Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio. Hou J, et al. Environ Sci Technol, 2018 Jul 17. PMID 29944347
  4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myoneurin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199768.1 → NP_956062.1  myoneurin

    See identical proteins and their annotated locations for NP_956062.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045441
    UniProtKB/Swiss-Prot
    Q7ZVR6
    Related
    ENSDARP00000016471.7, ENSDART00000003884.9
    Conserved Domains (5) summary
    smart00225
    Location:25 → 113
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:559 → 579
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:557 → 579
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain
    pfam13465
    Location:571 → 596
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    26328782..26343902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162774.5 → XP_005162831.1  myoneurin isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9Q5
    Conserved Domains (5) summary
    smart00225
    Location:25 → 113
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:557 → 577
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:555 → 577
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain
    pfam13465
    Location:569 → 594
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVR6.1 GenPept UniProtKB/Swiss-Prot:Q7ZVR6

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