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tpte transmembrane phosphatase with tensin homology [ Danio rerio (zebrafish) ]

Gene ID: 327292, updated on 14-Nov-2024

Summary

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Official Symbol
tpteprovided by ZNC
Official Full Name
transmembrane phosphatase with tensin homologyprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5503
See related
Ensembl:ENSDARG00000056985 AllianceGenome:ZFIN:ZDB-GENE-030131-5503
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
vsp; tpip; wu:fd20e11; wu:fi24b06
Summary
Enables monoatomic ion channel activity and phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Acts upstream of or within monoatomic ion transmembrane transport; phosphatidylinositol dephosphorylation; and regulation of endocytosis. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in blood vessel; gill; pleuroperitoneal region; and ventral mesoderm. Orthologous to human TPTE (transmembrane phosphatase with tensin homology) and TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tpte in Genome Data Viewer
Location:
chromosome: 10
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (24690684..24707956)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (24721177..24738504)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 1 Neighboring gene fibrinogen like 1B Neighboring gene sphingomyelin phosphodiesterase 1 Neighboring gene integrin-linked kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential Regulation of PI(4,5)P(2) Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin. Gomis-Perez C, et al. Front Mol Neurosci, 2017. PMID 28507506, Free PMC Article
  2. Evolution of the voltage sensor domain of the voltage-sensitive phosphoinositide phosphatase VSP/TPTE suggests a role as a proton channel in eutherian mammals. Sutton KA, et al. Mol Biol Evol, 2012 Sep. PMID 22396523, Free PMC Article
  3. Voltage-sensing phosphatase: actions and potentials. Okamura Y, et al. J Physiol, 2009 Feb 1. PMID 19074969, Free PMC Article
  4. Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor. Sakata S, et al. J Physiol, 2014 Mar 1. PMID 24277865, Free PMC Article
  5. Fluorescent protein voltage probes derived from ArcLight that respond to membrane voltage changes with fast kinetics. Han Z, et al. PLoS One, 2013. PMID 24312287, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of K364 next to the active site cysteine in voltage-dependent phosphatase activity of Ci-VSP.
    Title: Role of K364 next to the active site cysteine in voltage-dependent phosphatase activity of Ci-VSP.
  2. Measurements of the phosphatase activity toward phosphatidylinositol 4,5-bisphosphate revealed that both steps of voltage sensor activation are coupled to the tuning of phosphatase activities.
    Title: Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC113432

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative tyrosine-protein phosphatase TPTE
Names
Dr-VSP
voltage-sensing phosphoinositide phosphatase
NP_001020629.1
XP_005155316.1
XP_005155317.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025458.1 → NP_001020629.1  putative tyrosine-protein phosphatase TPTE

    See identical proteins and their annotated locations for NP_001020629.1

    Status: PROVISIONAL

    Source sequence(s)
    BC096934
    UniProtKB/TrEMBL
    Q4V9E4
    Related
    ENSDARP00000074004.3, ENSDART00000079549.4
    Conserved Domains (3) summary
    smart00404
    Location:270 → 365
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam00520
    Location:91 → 175
    Ion_trans; Ion transport protein
    pfam10409
    Location:373 → 510
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    24690684..24707956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155259.5 → XP_005155316.1  putative tyrosine-protein phosphatase TPTE isoform X1

    See identical proteins and their annotated locations for XP_005155316.1

    UniProtKB/TrEMBL
    A0A8M2B249, F1QG29
    Conserved Domains (3) summary
    smart00404
    Location:270 → 365
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam00520
    Location:90 → 175
    Ion_trans; Ion transport protein
    pfam10409
    Location:373 → 510
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  2. XM_005155260.5 → XP_005155317.1  putative tyrosine-protein phosphatase TPTE isoform X1

    See identical proteins and their annotated locations for XP_005155317.1

    UniProtKB/TrEMBL
    A0A8M2B249, F1QG29
    Related
    ENSDARP00000157510.1, ENSDART00000181600.1
    Conserved Domains (3) summary
    smart00404
    Location:270 → 365
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam00520
    Location:90 → 175
    Ion_trans; Ion transport protein
    pfam10409
    Location:373 → 510
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
Nucleotide Protein Strain
Heading Accession and Version

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