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nploc4 NPL4 homolog, ubiquitin recognition factor [ Danio rerio (zebrafish) ]

Gene ID: 327447, updated on 4-Jan-2025

Summary

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Official Symbol
nploc4provided by ZNC
Official Full Name
NPL4 homolog, ubiquitin recognition factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5658
See related
Ensembl:ENSDARG00000100487 AllianceGenome:ZFIN:ZDB-GENE-030131-5658
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
npl4; zgc:55988; wu:fi11f09
Summary
Predicted to enable ubiquitin binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Orthologous to human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See nploc4 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (35955878..35976925, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (36261623..36282670, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 213b Neighboring gene dynein, axonemal, intermediate chain 2a Neighboring gene phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b Neighboring gene oxidoreductase-like domain containing 1 Neighboring gene G protein-coupled receptor, class C, group 5, member C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear protein localization protein 4 homolog
Names
nuclear protein localization 4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199807.1 → NP_956101.1  nuclear protein localization protein 4 homolog

    See identical proteins and their annotated locations for NP_956101.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045845
    UniProtKB/TrEMBL
    A0A0R4IGH9, B2GTE1, Q7ZVI8
    Related
    ENSDARP00000133068.1, ENSDART00000165935.2
    Conserved Domains (5) summary
    COG5100
    Location:5 → 576
    NPL4; Nuclear pore protein [Nuclear structure]
    sd00029
    Location:600 → 619
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam05020
    Location:123 → 261
    zf-NPL4; NPL4 family, putative zinc binding region
    pfam05021
    Location:264 → 572
    NPL4; NPL4 family
    pfam11543
    Location:1 → 79
    UN_NPL4; Nuclear pore localization protein NPL4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    35955878..35976925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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