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rpa1 replication protein A1 [ Danio rerio (zebrafish) ]

Gene ID: 327491, updated on 14-Nov-2024

Summary

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Official Symbol
rpa1provided by ZNC
Official Full Name
replication protein A1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030912-3
See related
Ensembl:ENSDARG00000003938 AllianceGenome:ZFIN:ZDB-GENE-030912-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55337; zgc:77092; wu:fi14b08
Summary
Predicted to enable damaged DNA binding activity and single-stranded telomeric DNA binding activity. Acts upstream of or within heart development. Predicted to be located in nucleus. Predicted to be part of DNA replication factor A complex. Is expressed in head and pectoral fin. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See rpa1 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (26498339..26538989, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (26565463..26606113, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene diphthamide biosynthesis 1 Neighboring gene reticulon 4 receptor-like 1b Neighboring gene uncharacterized LOC137487755 Neighboring gene serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b Neighboring gene WD repeat domain 81

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of zebrafish Rad52 and replication protein A for oligonucleotide-mediated mutagenesis. Takahashi N, et al. Nucleic Acids Res, 2005 Aug 1. PMID 16061934, Free PMC Article
  2. Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish. Kamstra JH, et al. Sci Rep, 2018 Oct 18. PMID 30337673, Free PMC Article
  3. Distinct roles of Shh and Fgf signaling in regulating cell proliferation during zebrafish pectoral fin development. Prykhozhij SV, et al. BMC Dev Biol, 2008 Sep 23. PMID 18811955, Free PMC Article
  4. Knock-In Strategy for Editing Human and Zebrafish Mitochondrial DNA Using Mito-CRISPR/Cas9 System. Bian WP, et al. ACS Synth Biol, 2019 Apr 19. PMID 30955321
  5. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Milan DJ, et al. Circulation, 2009 Aug 18. PMID 19652097, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables single-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor A complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
replication protein A 70 kDa DNA-binding subunit
Names
RF-A protein 1
RP-A p70
replication factor A protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199811.2 → NP_956105.2  replication protein A 70 kDa DNA-binding subunit

    See identical proteins and their annotated locations for NP_956105.2

    Status: PROVISIONAL

    Source sequence(s)
    BC066711
    UniProtKB/Swiss-Prot
    Q6NY74
    Related
    ENSDARP00000029067.5, ENSDART00000032880.6
    Conserved Domains (5) summary
    cd04474
    Location:173 → 275
    RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    cd04477
    Location:8 → 102
    RPA1N; RPA1N: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all ...
    TIGR00617
    Location:3 → 597
    rpa1; replication factor-a protein 1 (rpa1)
    pfam08646
    Location:446 → 591
    Rep_fac-A_C; Replication factor-A C terminal domain
    pfam16900
    Location:292 → 388
    REPA_OB_2; Replication protein A OB domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    26498339..26538989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NY74.1 GenPept UniProtKB/Swiss-Prot:Q6NY74

Gene LinkOut

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