U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ckmt2a creatine kinase, mitochondrial 2a (sarcomeric) [ Danio rerio (zebrafish) ]

Gene ID: 327506, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
ckmt2aprovided by ZNC
Official Full Name
creatine kinase, mitochondrial 2a (sarcomeric)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5717
See related
Ensembl:ENSDARG00000069615 AllianceGenome:ZFIN:ZDB-GENE-030131-5717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi14g08; zgc:56085; wu:fi14g08
Summary
Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in mitochondrion. Is expressed in myotome and retina. Orthologous to human CKMT2 (creatine kinase, mitochondrial 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ckmt2a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (3111590..3130409)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (3061647..3079528, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 34Ba Neighboring gene Ras protein-specific guanine nucleotide-releasing factor 2a Neighboring gene ubiquitin-conjugating enzyme E2L 3a Neighboring gene hypermethylated in cancer 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Comprehensive transcriptome analysis reveal key molecular events in the pearl oyster after pre-grafting conditioning. Jiao Y, et al. Fish Shellfish Immunol, 2019 Sep. PMID 31195116
  2. Cardiomyocyte heterogeneity during zebrafish development and regeneration. Tsedeke AT, et al. Dev Biol, 2021 Aug. PMID 33857482
  3. Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. Guerra A, et al. Elife, 2018 May 15. PMID 29762122, Free PMC Article
  4. A sart1 Zebrafish Mutant Results in Developmental Defects in the Central Nervous System. Henson HE, et al. Cells, 2020 Oct 22. PMID 33105605, Free PMC Article
  5. Proteomic analysis of anatoxin-a acute toxicity in zebrafish reveals gender specific responses and additional mechanisms of cell stress. Carneiro M, et al. Ecotoxicol Environ Saf, 2015 Oct. PMID 26046835

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables creatine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables creatine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphocreatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphocreatine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
creatine kinase, mitochondrial 2a (sarcomeric)
NP_001295537.1
NP_001295538.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308608.2 → NP_001295537.1  creatine kinase, mitochondrial 2a (sarcomeric) isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    EH115450, EH439325, EH461171, EH612110, LO018559
    UniProtKB/TrEMBL
    A0A2R9YJH5, A0A8M1P1Z0
    Related
    ENSDARP00000092223.5, ENSDART00000101449.5
    Conserved Domains (1) summary
    cd00716
    Location:49 → 406
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

  2. NM_001308609.2 → NP_001295538.1  creatine kinase, mitochondrial 2a (sarcomeric) isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate internal exon compared to variant 1. The encoded isoform is the same length but differs in amino acid sequence compared to isoform 1.
    Source sequence(s)
    EH115450, EH439325, EH461171, EH612110, LO018559
    UniProtKB/TrEMBL
    A0A0R4IFJ7, A0A8M1P728
    Related
    ENSDARP00000134106.2, ENSDART00000168670.3
    Conserved Domains (1) summary
    cd00716
    Location:49 → 406
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    3111590..3130409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394799.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    11641..29915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199816.1: Suppressed sequence

    Description
    NM_199816.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.