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hpxa hemopexin a [ Danio rerio (zebrafish) ]

Gene ID: 327588, updated on 9-Dec-2024

Summary

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Official Symbol
hpxaprovided by ZNC
Official Full Name
hemopexin aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5773
See related
Ensembl:ENSDARG00000012609 AllianceGenome:ZFIN:ZDB-GENE-030131-5773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hpx; hpx a; wu:fi17f11; wu:fi19a10
Summary
Predicted to enable heme transmembrane transporter activity and metal ion binding activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in blood; liver; and male organism. Orthologous to human HPX (hemopexin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See hpxa in Genome Data Viewer
Location:
chromosome: 9
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (32840928..32847639, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (33030182..33036893, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene myxovirus (influenza virus) resistance C Neighboring gene myxovirus (influenza virus) resistance E Neighboring gene ankyrin repeat domain 50-like Neighboring gene uncharacterized LOC101883176

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Reorganization of low-molecular-weight fraction of plasma proteins in the annual cycle of cyprinidae. Andreeva AM, et al. Biochemistry (Mosc), 2015 Feb. PMID 25756535
  2. Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development. O'Shields B, et al. Biochim Biophys Acta, 2014 Sep. PMID 24751692, Free PMC Article
  3. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. Oka T, et al. BMC Physiol, 2010 Oct 21. PMID 20961460, Free PMC Article
  4. Global gene expression analysis reveals dynamic and developmental stage-dependent enrichment of lead-induced neurological gene alterations. Peterson SM, et al. Environ Health Perspect, 2011 May. PMID 21147602, Free PMC Article
  5. Plasmalogens improve swimming performance by modulating the expression of genes involved in amino acid and lipid metabolism, oxidative stress, and ferroptosis in an Alzheimer's disease zebrafish model. Feng J, et al. Food Funct, 2021 Nov 29. PMID 34783821

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heme transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within heme transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hemopexin
NP_001315463.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328534.1 → NP_001315463.1  hemopexin precursor

    Status: VALIDATED

    Source sequence(s)
    BC056563, CT030044
    UniProtKB/Swiss-Prot
    A9JSW7, Q6PHG2
    Related
    ENSDARP00000111337.2, ENSDART00000121506.4
    Conserved Domains (2) summary
    cd00094
    Location:49 → 243
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cl02471
    Location:257 → 445
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    32840928..32847639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001111147.1: Suppressed sequence

    Description
    NM_001111147.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PHG2.2 GenPept UniProtKB/Swiss-Prot:Q6PHG2

Gene LinkOut

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