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Zfp616 zinc finger protein 616 [ Mus musculus (house mouse) ]

Gene ID: 327963, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp616provided by MGI
Official Full Name
zinc finger protein 616provided by MGI
Primary source
MGI:MGI:3650906
See related
Ensembl:ENSMUSG00000069476 AllianceGenome:MGI:3650906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm12330
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to zinc ion; regulation of DNA-templated transcription; and ribosome biogenesis. Orthologous to human ZNF658 (zinc finger protein 658). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Zfp616 in Genome Data Viewer
Location:
11 B4; 11 45.74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (73951723..73978127)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74060897..74087301)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 3 subfamily A member 10 Neighboring gene olfactory receptor family 3 subfamily A member 4 Neighboring gene high mobility group box 2 pseudogene Neighboring gene olfactory receptor family 3 subfamily A member 15, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_29945 Neighboring gene olfactory receptor family 3 subfamily A member 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to zinc ion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 616
Names
KRAB box containing protein
novel KRAB box containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177570.1 → NP_001171041.1  zinc finger protein 616

    Status: VALIDATED

    Source sequence(s)
    AL611937
    Consensus CDS
    CCDS56793.1
    UniProtKB/TrEMBL
    J3QN14
    Related
    ENSMUSP00000136549.2, ENSMUST00000178159.2
    Conserved Domains (4) summary
    COG5048
    Location:506 → 914
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:707 → 727
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:705 → 727
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:943 → 968
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    73951723..73978127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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