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Zmiz1 zinc finger, MIZ-type containing 1 [ Mus musculus (house mouse) ]

Gene ID: 328365, updated on 17-Aug-2024

Summary

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Official Symbol
Zmiz1provided by MGI
Official Full Name
zinc finger, MIZ-type containing 1provided by MGI
Primary source
MGI:MGI:3040693
See related
Ensembl:ENSMUSG00000007817 AllianceGenome:MGI:3040693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rai17; Zimp10; Gm10397; E330020C23; I920194n01
Summary
Predicted to enable SMAD binding activity and nuclear receptor coactivator activity. Involved in positive regulation of Notch signaling pathway and positive regulation of T cell differentiation. Acts upstream of or within several processes, including circulatory system development; positive regulation of fibroblast proliferation; and vitellogenesis. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including embryo ectoderm; genitourinary system; limb; limb bud; and sensory organ. Orthologous to human ZMIZ1 (zinc finger MIZ-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 35.4), limb E14.5 (RPKM 30.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 15.03 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (25458299..25667167)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (25457875..25666743)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Zmiz1 opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_36211 Neighboring gene predicted gene, 41113 Neighboring gene STARR-seq mESC enhancer starr_36213 Neighboring gene predicted gene, 32645 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26273941-26274105 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26336816-26337032 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26336443-26336626 Neighboring gene STARR-positive B cell enhancer mm9_chr14:26346851-26347151 Neighboring gene microRNA 3075 Neighboring gene STARR-positive B cell enhancer mm9_chr14:26385131-26385431 Neighboring gene RIKEN cDNA 4931406H21 gene Neighboring gene VISTA enhancer mm1678 Neighboring gene STARR-seq mESC enhancer starr_36215 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26428962-26429115 Neighboring gene predicted gene, 32497 Neighboring gene STARR-seq mESC enhancer starr_36220 Neighboring gene immune system associated SCR family kinase partner Neighboring gene predicted gene, 52102 Neighboring gene RIKEN cDNA 1700054O19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26513358-26513673 Neighboring gene peptidylprolyl isomerase F, opposite strand Neighboring gene peptidylprolyl isomerase F (cyclophilin F)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer. Rogers LM, et al. J Invest Dermatol, 2013 Jul. PMID 23426136, Free PMC Article
  2. Spatial and temporal expression of Zimp7 and Zimp10 PIAS-like proteins in the developing mouse embryo. Rodriguez-Magadán H, et al. Gene Expr Patterns, 2008 Feb. PMID 18053775
  3. Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development. Wang Q, et al. Blood, 2018 Sep 20. PMID 30076146, Free PMC Article
  4. Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding. Alghamdi TA, et al. Mol Metab, 2022 Dec. PMID 36307047, Free PMC Article
  5. Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias. Rakowski LA, et al. Cancer Res, 2013 Jan 15. PMID 23161489, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function.
    Title: Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function.
  2. Zmiz1 is required for mature beta-cell function and mass expansion upon high fat feeding.
    Title: Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding.
  3. Zmiz1 is a context-specific cofactor for Notch1 during Notch/Myc-dependent thymocyte proliferation, whether normal or malignant.
    Title: Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.
  4. Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer.
    Title: Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer.
  5. we show that activated NOTCH1 and ZMIZ1 collaborate to induce T-ALL in mice.
    Title: Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.
  6. Zimp10 is found in somatic cells, outside the testis cords and ceases to be expressed in the adult testis.
    Title: Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads.
  7. provides evidence to demonstrate a crucial role for Zimp10 in vasculogenesis
    Title: The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development.
  8. A physiological role for Zimp10 in regulating Smad3/4-mediated transcription is demonstrated in mouse embryonic fibroblasts.
    Title: The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular senescence IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyramidal neuron migration to cerebral cortex ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vitellogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger MIZ domain-containing protein 1
Names
PIAS-like protein Zimp10
retinoic acid induced 17
retinoic acid-induced protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310666.1 → NP_001297595.1  zinc finger MIZ domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001297595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AK132106, AK138053, BC058646, BQ748452, BU059092
    Consensus CDS
    CCDS79280.1
    UniProtKB/Swiss-Prot
    Q6P1E1
    UniProtKB/TrEMBL
    Q3V215
    Related
    ENSMUSP00000007961.9, ENSMUST00000007961.15
    Conserved Domains (2) summary
    cd16791
    Location:740 → 787
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    cl26464
    Location:192 → 556
    Atrophin-1; Atrophin-1 family

  2. NM_183208.4 → NP_899031.2  zinc finger MIZ domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_899031.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK132106, AK138053, BC065120, BQ748452, CF732350
    Consensus CDS
    CCDS26873.1
    UniProtKB/Swiss-Prot
    Q6P1E1, Q6PDK9, Q6PF85, Q8BW47
    Related
    ENSMUSP00000124863.2, ENSMUST00000162645.8
    Conserved Domains (3) summary
    PHA03247
    Location:119 → 546
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:746 → 793
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8 → 100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    25458299..25667167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519134.4 → XP_006519197.1  zinc finger MIZ domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:119 → 546
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:746 → 793
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8 → 100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

  2. XM_036158678.1 → XP_036014571.1  zinc finger MIZ domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:118 → 556
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:740 → 787
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8 → 100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

  3. XM_036158677.1 → XP_036014570.1  zinc finger MIZ domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6P1E1, Q6PDK9, Q6PF85, Q8BW47
    Conserved Domains (3) summary
    PHA03247
    Location:119 → 546
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:746 → 793
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8 → 100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

  4. XM_030247864.2 → XP_030103724.1  zinc finger MIZ domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:61 → 439
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:622 → 669
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  5. XM_030247865.2 → XP_030103725.1  zinc finger MIZ domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:68 → 432
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:616 → 663
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  6. XM_036158679.1 → XP_036014572.1  zinc finger MIZ domain-containing protein 1 isoform X6

    Conserved Domains (2) summary
    PHA03247
    Location:68 → 432
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:616 → 663
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

  7. XM_030247863.2 → XP_030103723.1  zinc finger MIZ domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:61 → 439
    PHA03247; large tegument protein UL36; Provisional
    cd16791
    Location:622 → 669
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033402.2: Suppressed sequence

    Description
    NM_001033402.2: This RefSeq was temporarily suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1E1.1 GenPept UniProtKB/Swiss-Prot:Q6P1E1

Gene LinkOut

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