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Il19 interleukin 19 [ Mus musculus (house mouse) ]

Gene ID: 329244, updated on 11-Nov-2024

Summary

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Official Symbol
Il19provided by MGI
Official Full Name
interleukin 19provided by MGI
Primary source
MGI:MGI:1890472
See related
Ensembl:ENSMUSG00000016524 AllianceGenome:MGI:1890472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cytokine activity. Involved in negative regulation of low-density lipoprotein particle clearance. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; and reactive oxygen species metabolic process. Predicted to be located in extracellular space. Orthologous to human IL19 (interleukin 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Il19 in Genome Data Viewer
Location:
1 E4; 1 56.89 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130860393..130873194, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130932656..130945457, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 24 Neighboring gene STARR-seq mESC enhancer starr_02206 Neighboring gene interleukin 20 Neighboring gene predicted gene, 41952 Neighboring gene STARR-positive B cell enhancer ABC_E9479 Neighboring gene STARR-positive B cell enhancer ABC_E7747 Neighboring gene interleukin 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation. Horiuchi H, et al. Front Immunol, 2021. PMID 33776998, Free PMC Article
  2. Interleukin-19 induces angiogenesis in the absence of hypoxia by direct and indirect immune mechanisms. Kako F, et al. Am J Physiol Cell Physiol, 2016 Jun 1. PMID 27053520, Free PMC Article
  3. Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis. Fujimoto Y, et al. Naunyn Schmiedebergs Arch Pharmacol, 2017 Mar. PMID 27942772
  4. Interleukin 19 reduces inflammation in chemically induced experimental colitis. Matsuo Y, et al. Int Immunopharmacol, 2015 Dec. PMID 26476684
  5. Interleukin-19 acts as a negative autocrine regulator of activated microglia. Horiuchi H, et al. PLoS One, 2015. PMID 25794104, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-19 in Bone Marrow Contributes to Bone Loss Via Suppressing Osteogenic Differentiation Potential of BMSCs in Old Mice.
    Title: Interleukin-19 in Bone Marrow Contributes to Bone Loss Via Suppressing Osteogenic Differentiation Potential of BMSCs in Old Mice.
  2. Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways.
    Title: Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways.
  3. Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid.
    Title: Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid.
  4. The colonic interleukin-19 aggravates the dextran sodium sulfate/stress-induced comorbidities due to colitis and anxiety.
    Title: The colonic interleukin-19 aggravates the dextran sodium sulfate/stress-induced comorbidities due to colitis and anxiety.
  5. Interleukin 19 suppresses RANKL-induced osteoclastogenesis via the inhibition of NF-kappaB and p38MAPK activation and c-Fos expression in RAW264.7 cells.
    Title: Interleukin 19 suppresses RANKL-induced osteoclastogenesis via the inhibition of NF-κB and p38MAPK activation and c-Fos expression in RAW264.7 cells.
  6. Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis.
    Title: Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis.
  7. IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism.
    Title: IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism.
  8. Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment.
    Title: Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment.
  9. Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation.
    Title: Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation.
  10. Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation.
    Title: Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within interleukin-6 production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interleukin-19
Names
IL-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009940.2 → NP_001009940.1  interleukin-19 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001009940.1

    Status: VALIDATED

    Source sequence(s)
    AC165322
    Consensus CDS
    CCDS15264.1
    UniProtKB/Swiss-Prot
    Q8CJ70
    UniProtKB/TrEMBL
    Q14BK1
    Related
    ENSMUSP00000108084.2, ENSMUST00000112465.2
    Conserved Domains (1) summary
    cl02501
    Location:34 → 167
    IL10; Interleukin 10

  2. NM_001355135.1 → NP_001342064.1  interleukin-19 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165322
    Consensus CDS
    CCDS87872.1
    UniProtKB/TrEMBL
    A0A087WST1
    Related
    ENSMUSP00000141175.2, ENSMUST00000187916.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130860393..130873194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529705.1 → XP_006529768.1  interleukin-19 isoform X1

    Conserved Domains (1) summary
    cl02501
    Location:53 → 182
    IL10; Interleukin 10

  2. XM_030255026.1 → XP_030110886.1  interleukin-19 isoform X2

    UniProtKB/TrEMBL
    A0A087WST1

  3. XM_030255027.1 → XP_030110887.1  interleukin-19 isoform X2

    UniProtKB/TrEMBL
    A0A087WST1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CJ70.1 GenPept UniProtKB/Swiss-Prot:Q8CJ70

Gene LinkOut

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