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Med12l mediator complex subunit 12-like [ Mus musculus (house mouse) ]

Gene ID: 329650, updated on 11-Nov-2024

Summary

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Official Symbol
Med12lprovided by MGI
Official Full Name
mediator complex subunit 12-likeprovided by MGI
Primary source
MGI:MGI:2139916
See related
Ensembl:ENSMUSG00000056476 AllianceGenome:MGI:2139916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRALPUSH; A130035F20; A630079M02
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Orthologous to human MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 4.7), CNS E18 (RPKM 3.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Med12l in Genome Data Viewer
Location:
3 D; 3 28.89 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (58912820..59225867)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59005419..59318446)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 6 Neighboring gene predicted gene, 25572 Neighboring gene STARR-positive B cell enhancer ABC_E6054 Neighboring gene STARR-seq mESC enhancer starr_07762 Neighboring gene STARR-seq mESC enhancer starr_07763 Neighboring gene G protein-coupled receptor 171 Neighboring gene RIKEN cDNA F630111L10 gene Neighboring gene purinergic receptor P2Y, G-protein coupled, 14 Neighboring gene STARR-seq mESC enhancer starr_07764 Neighboring gene STARR-seq mESC enhancer starr_07765 Neighboring gene predicted gene, 51434 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene purinergic receptor P2Y, G-protein coupled 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:59062055-59062302 Neighboring gene STARR-seq mESC enhancer starr_07766 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene nuclear encoded tRNA valine 1 (anticodon CAC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. Vogl MR, et al. J Neurosci, 2013 Apr 10. PMID 23575864, Free PMC Article
  2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 12-like protein
Names
mediator complex subunit 12-like protein
mediator of RNA polymerase II transcription, subunit 12 homolog-like
no opposite paired repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177855.3 → NP_808523.2  mediator of RNA polymerase II transcription subunit 12-like protein

    Status: VALIDATED

    Source sequence(s)
    AA409741, AC122038, AK018323, AK037666, AK047743, BB646790, BP757618, BP757619, CA316095, CA318113, CB520516, CK638338
    Consensus CDS
    CCDS79912.1
    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    UniProtKB/TrEMBL
    A0A0G2JET8
    Related
    ENSMUSP00000142903.2, ENSMUST00000199659.5
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1838 → 2062
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283 → 765
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    58912820..59225867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252646.2 → XP_030108506.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1849 → 2073
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  2. XM_036163137.1 → XP_036019030.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1814 → 2040
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 741
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  3. XM_017319618.3 → XP_017175107.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X11

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1849 → 1931
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  4. XM_006501593.5 → XP_006501656.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1849 → 1931
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  5. XM_006501592.5 → XP_006501655.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1849 → 2068
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  6. XM_006501589.5 → XP_006501652.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X6

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1849 → 2073
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  7. XM_006501591.5 → XP_006501654.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X8

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1849 → 2068
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  8. XM_030252645.2 → XP_030108505.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1849 → 2073
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  9. XM_030252647.2 → XP_030108507.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X4

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    UniProtKB/TrEMBL
    A0A0G2JET8
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1838 → 2062
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283 → 765
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  10. XM_006501587.5 → XP_006501650.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X3

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1844 → 2068
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  11. XM_006501586.5 → XP_006501649.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1848 → 2072
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  12. XM_006501588.5 → XP_006501651.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1814 → 2040
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 741
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  13. XM_030252649.2 → XP_030108509.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X7

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1803 → 2027
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283 → 730
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

  14. XM_030252648.1 → XP_030108508.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

    UniProtKB/Swiss-Prot
    Q6ZPF2, Q8BQM9, Q8C9E3
    Conserved Domains (3) summary
    pfam09497
    Location:106 → 172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:1814 → 2040
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294 → 741
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

RNA

  1. XR_004941335.1 RNA Sequence

  2. XR_004941334.1 RNA Sequence

  3. XR_003954333.2 RNA Sequence

  4. XR_375531.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQM9.2 GenPept UniProtKB/Swiss-Prot:Q8BQM9

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