Ttll10 tubulin tyrosine ligase-like family, member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttll10provided by MGI
Official Full Name: tubulin tyrosine ligase-like family, member 10provided by MGI
Primary source: MGI:MGI:1921855
See related: Ensembl:ENSMUSG00000029074 AllianceGenome:MGI:1921855
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ttll5; 4833412E22Rik; 4930595O22Rik
Summary: Enables protein-glycine ligase activity, elongating. Involved in protein polyglycylation. Located in axoneme and microtubule cytoskeleton. Is expressed in white fat. Orthologous to human TTLL10 (tubulin tyrosine ligase like 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 132.3) and colon adult (RPKM 7.2) See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4 E2; 4 87.82 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (156119292..156135274, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (156034835..156050817, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TTLL10 can strongly glycylate tubulin in a TTLL8-dependent manner. Furthermore, these two TTLL proteins can glycylate unidentified 170-, 110-, 75-, 40-, 35-, and 30-kDa acidic proteins.
Title: TTLL10 can perform tubulin glycylation when co-expressed with TTLL8.
Recombinant TTLL10 incorporated glycine into recombinant nucleosome assembly protein 1 in vitro.
Title: TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1.
has a polyglycylase (i.e. glycine ligase) activity for nucleosome assembly protein 1 (NAP1).
Title: TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3)

General gene information

Go to the top of the page Help

Markers

D4Mon15 (e-PCR)
- UniSTS:240979

D4Mon16 (e-PCR)
- UniSTS:240980

D4Mon17 (e-PCR)
- UniSTS:240981

D4Mon18 (e-PCR)
- UniSTS:240982

D4Mon2 (e-PCR)
- UniSTS:240984

D4Mon20 (e-PCR)
- UniSTS:240985

NoName (e-PCR)
- UniSTS:492140

NoName (e-PCR)
- UniSTS:235121

D4Mon68 (e-PCR)
- UniSTS:241021

D4Mon9 (e-PCR)
- UniSTS:241023

AU022799 (e-PCR)
- UniSTS:207744

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein-glycine ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-glycine ligase activity, elongating	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glycine ligase activity, elongating	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein polyglycylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyglycylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein polyglycylase TTLL10

Names: tubulin tyrosine ligase-like family, member 5; tubulin--tyrosine ligase-like protein 10

NP_001355570.1

EC 6.-.-.-

NP_083540.1

EC 6.-.-.-

XP_036020095.1

EC 6.-.-.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368641.1 → NP_001355570.1 protein polyglycylase TTLL10 isoform 2

Status: VALIDATED

Source sequence(s)

AL627204

Consensus CDS

CCDS89873.1

UniProtKB/Swiss-Prot

A4Q9F3, Q3V0K4

UniProtKB/TrEMBL

V9GXT8

Related

ENSMUSP00000139316.2, ENSMUST00000184348.8

Conserved Domains (1) summary

cl17255
Location:272 → 525

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
NM_029264.2 → NP_083540.1 protein polyglycylase TTLL10 isoform 1

See identical proteins and their annotated locations for NP_083540.1

Status: VALIDATED

Source sequence(s)

AK133079

Consensus CDS

CCDS19058.1

UniProtKB/Swiss-Prot

A4Q9F3, Q3V0K4

UniProtKB/TrEMBL

B1ASM0

Related

ENSMUSP00000055671.9, ENSMUST00000051509.15

Conserved Domains (1) summary

cl17255
Location:243 → 496

ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

156119292..156135274 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164202.1 → XP_036020095.1 protein polyglycylase TTLL10 isoform X1

Conserved Domains (1) summary

cl17255
Location:292 → 436

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain