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Mblac1 metallo-beta-lactamase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 330216, updated on 28-Oct-2024

Summary

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Official Symbol
Mblac1provided by MGI
Official Full Name
metallo-beta-lactamase domain containing 1provided by MGI
Primary source
MGI:MGI:2679717
See related
Ensembl:ENSMUSG00000049285 AllianceGenome:MGI:2679717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable RNA endonuclease activity and metal ion binding activity. Predicted to be involved in histone mRNA metabolic process; mRNA 3'-end processing; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human MBLAC1 (metallo-beta-lactamase domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human all
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Genomic context

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See Mblac1 in Genome Data Viewer
Location:
5 G2; 5 76.98 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138192576..138193883)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138194314..138195621)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex AP-4, mu 1 Neighboring gene STARR-seq mESC enhancer starr_14665 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene predicted gene 454 Neighboring gene neurexophilin and PC-esterase domain family, member 5 Neighboring gene predicted gene, 22956

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice. Ceyhan B, et al. Annu Int Conf IEEE Eng Med Biol Soc, 2023 Jul. PMID 38083729
  2. Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo β-lactamase, MBLAC1. Gibson CL , et al. Mol Omics, 2018 Jun 12. PMID 29868674, Free PMC Article
  3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice.
    Title: Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC49416

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in histone mRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in histone mRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
metallo-beta-lactamase domain-containing protein 1
Names
endoribonuclease MBLAC1
NP_808546.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177878.3 → NP_808546.1  metallo-beta-lactamase domain-containing protein 1

    See identical proteins and their annotated locations for NP_808546.1

    Status: VALIDATED

    Source sequence(s)
    AI314927, AK049381
    Consensus CDS
    CCDS19796.1
    UniProtKB/Swiss-Prot
    Q8BWY4, Q8CHU7
    Related
    ENSMUSP00000052869.5, ENSMUST00000057773.5
    Conserved Domains (2) summary
    COG0491
    Location:81 → 244
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cd07711
    Location:24 → 240
    MBLAC1-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 1 and related proteins; MBL-fold metallo hydrolase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138192576..138193883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWY4.1 GenPept UniProtKB/Swiss-Prot:Q8BWY4

Gene LinkOut

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