Dd Dullard [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ddprovided by FlyBase
Official Full Name: Dullardprovided by FlyBase
Primary source: FLYBASE:FBgn0029067
Locus tag: Dmel_CG1696
See related: AllianceGenome:FB:FBgn0029067
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 20151539; anon-WO03040301.167; BcDNA:LD08201; CG1696; Ctdnep1; DD; ddd; Dmel\CG1696; l(1)G0269
Summary: Enables protein serine/threonine phosphatase activity. Involved in imaginal disc-derived wing vein specification; negative regulation of BMP signaling pathway; and protein dephosphorylation. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Is expressed in adult head and organism. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 19F4-19F4; 1-65 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (21319791..21324009, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (21190818..21195036, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms.
Title: Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms.
Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division.
Title: Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division.
The phosphatase Dullard is involved in dephosphorylating the Drosophila R-Smad, Mad, and is integral in controlling BMP signal duration.
Title: Drosophila Dullard functions as a Mad phosphatase to terminate BMP signaling.
Manipulating expression levels of either the Drosophila Dullard gene, d-dullard (ddd) or the Lipin gene affected wing vein formation in a manner suggesting a negative effect on bone morphogenetic protein signaling. [Dullard]
Title: Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear envelope organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of nuclear membrane biogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Nem1-Spo7 phosphatase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein serine/threonine phosphatase complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: dullard

Names: CG1696-PA; CG1696-PB; CG1696-PC; Dd-PA; Dd-PB; Dd-PC; d-dullard; lethal (1) G0269

NP_001285515.1

EC 3.1.3.-

EC 3.1.3.16

NP_001285516.1

EC 3.1.3.-

EC 3.1.3.16

NP_608449.1

EC 3.1.3.-

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

21319791..21324009 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298586.1 → NP_001285515.1 dullard, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285515.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JCV6

Conserved Domains (1) summary

TIGR02251
Location:57 → 225

HIF-SF_euk; Dullard-like phosphatase domain
NM_001298587.1 → NP_001285516.1 dullard, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285516.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JEK6

Conserved Domains (1) summary

cl21460
Location:60 → 167

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_134605.3 → NP_608449.1 dullard, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608449.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MT79, Q9VRG7

Related

FBpp0076921

Conserved Domains (1) summary

TIGR02251
Location:60 → 228

HIF-SF_euk; Dullard-like phosphatase domain