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Ppp1r13l protein phosphatase 1, regulatory subunit 13 like [ Mus musculus (house mouse) ]

Gene ID: 333654, updated on 4-Jan-2025

Summary

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Official Symbol
Ppp1r13lprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 13 likeprovided by MGI
Primary source
MGI:MGI:3525053
See related
Ensembl:ENSMUSG00000040734 AllianceGenome:MGI:3525053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
wa3; IASPP; Nkip1
Summary
Predicted to enable identical protein binding activity. Involved in negative regulation of inflammatory response. Acts upstream of or within several processes, including cardiac muscle contraction; heart development; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cell junction; cytosol; and intercellular bridge. Is expressed in esophagus; sensory organ; submandibular gland primordium; and vibrissa. Used to study arrhythmogenic right ventricular cardiomyopathy. Orthologous to human PPP1R13L (protein phosphatase 1 regulatory subunit 13 like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in testis adult (RPKM 16.3), stomach adult (RPKM 11.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp1r13l in Genome Data Viewer
Location:
7 A3; 7 9.62 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19093639..19112465)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19359724..19378540)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D830036C21 gene Neighboring gene VISTA enhancer mm567 Neighboring gene STARR-positive B cell enhancer ABC_E10427 Neighboring gene STARR-positive B cell enhancer ABC_E1719 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 1 Neighboring gene STARR-positive B cell enhancer ABC_E6519 Neighboring gene RNA polymerase I subunit G Neighboring gene STARR-seq mESC enhancer starr_18201 Neighboring gene STARR-positive B cell enhancer mm9_chr7:19967137-19967438 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 2 Neighboring gene microRNA 343 Neighboring gene kinesin light chain 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene. Toonen J, et al. BMC Genet, 2012 Aug 28. PMID 22928477, Free PMC Article
  2. MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke. Liu X, et al. Stroke, 2013 Jul. PMID 23696548
  3. iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis. Yagudin T, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Jan 12. PMID 33128543
  4. Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury. Li Y, et al. Cell Death Differ, 2020 Sep. PMID 32203170, Free PMC Article
  5. p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer. Miller P, et al. Cell Death Differ, 2023 Jul. PMID 37270580, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer.
    Title: p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer.
  2. Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury.
    Title: Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury.
  3. Upregulation of iASPP ameliorates hypoxia/reoxygenation-induced apoptosis and oxidative stress in cardiomyocytes by upregulating Nrf2 signaling.
    Title: Upregulation of iASPP ameliorates hypoxia/reoxygenation-induced apoptosis and oxidative stress in cardiomyocytes by upregulating Nrf2 signaling.
  4. iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis.
    Title: iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis.
  5. The identification of a cell autonomous role of iASPP deficiency in causing cardiocutaneous syndrome, impaired eyelid development and wound healing suggests that variants in the iASPP gene also may contribute to polygenic heart and skin diseases.
    Title: Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders.
  6. miR-182 plays an aggressive role in the cerebral ischemia injury, and this is associated with inhibited iASPP expression.
    Title: MicroRNA-182 aggravates cerebral ischemia injury by targeting inhibitory member of the ASPP family (iASPP).
  7. iASPP expression may act as a predictive marker of prostate cancer progression.
    Title: Nuclear iASPP may facilitate prostate cancer progression.
  8. These data demonstrate that by interacting with desmoplakin and desmin, iASPP is an important regulator of desmosomal function both in vitro and in vivo.
    Title: iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death.
  9. p53-mediated neuronal cell death after stroke can be nontranscriptionally regulated by a novel mechanism involving suppression of endogenous cell death inhibitors by miR-124.
    Title: MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke.
  10. PPP1R13L has an essential role in embryonic eyelid closure as well in development of meibomian glands and the anterior segment of the eye
    Title: Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac right ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hair cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organismal-level homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ventricular cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
relA-associated inhibitor
Names
NFkB interacting protein 1
PPP1R13B-like protein
inhibitor of ASPP protein
protein iASPP
protein phosphatase 1, regulatory (inhibitor) subunit 13 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010836.4 → NP_001010836.1  relA-associated inhibitor

    See identical proteins and their annotated locations for NP_001010836.1

    Status: VALIDATED

    Source sequence(s)
    AC118017, AC148988
    Consensus CDS
    CCDS20899.1
    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Related
    ENSMUSP00000047839.8, ENSMUST00000047621.14
    Conserved Domains (4) summary
    cd11952
    Location:757 → 813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46 → 364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627 → 653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627 → 713
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001419335.1 → NP_001406264.1  relA-associated inhibitor

    Status: VALIDATED

    Source sequence(s)
    AC118017, AC148988
    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19093639..19112465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540128.4 → XP_006540191.1  relA-associated inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006540191.1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757 → 813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46 → 364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627 → 653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627 → 713
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006540126.3 → XP_006540189.1  relA-associated inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006540189.1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757 → 813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46 → 364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627 → 653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627 → 713
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_036153184.1 → XP_036009077.1  relA-associated inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757 → 813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46 → 364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627 → 653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627 → 713
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_006540127.5 → XP_006540190.1  relA-associated inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006540190.1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757 → 813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46 → 364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627 → 653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627 → 713
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_030242701.2 → XP_030098561.1  relA-associated inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757 → 813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46 → 364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627 → 653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627 → 713
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_030242700.2 → XP_030098560.1  relA-associated inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q5I1X5
    UniProtKB/TrEMBL
    Q3TCU2
    Conserved Domains (4) summary
    cd11952
    Location:757 → 813
    SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
    PHA03247
    Location:46 → 364
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:627 → 653
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:627 → 713
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I1X5.1 GenPept UniProtKB/Swiss-Prot:Q5I1X5

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