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eif3c eukaryotic translation initiation factor 3, subunit C [ Danio rerio (zebrafish) ]

Gene ID: 334234, updated on 2-Nov-2024

Summary

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Official Symbol
eif3cprovided by ZNC
Official Full Name
eukaryotic translation initiation factor 3, subunit Cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6166
See related
Ensembl:ENSDARG00000016443 AllianceGenome:ZFIN:ZDB-GENE-030131-6166
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
eif3s8; fi37c04; zgc:66128; wu:fb34a08; wu:fi37c04
Summary
Predicted to enable translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Orthologous to several human genes including EIF3C (eukaryotic translation initiation factor 3 subunit C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See eif3c in Genome Data Viewer
Location:
chromosome: 12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (3944229..3962374, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (3907464..3925627, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 6 Neighboring gene zgc:92040 Neighboring gene protein phosphatase 4, catalytic subunit b Neighboring gene si:ch211-136m16.8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development. Choudhuri A, et al. Dev Dyn, 2010 Jun. PMID 20503360, Free PMC Article
  2. Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. Lundby A, et al. Nat Methods, 2014 Aug. PMID 24952909, Free PMC Article
  3. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Frøyset AK, et al. Sci Rep, 2016 Jul 12. PMID 27404450, Free PMC Article
  4. Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. Seiler C, et al. PLoS One, 2015. PMID 26161877, Free PMC Article
  5. prpf4 is essential for cell survival and posterior lateral line primordium migration in zebrafish. Wang Y, et al. J Genet Genomics, 2018 Aug 20. PMID 30174136

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit C
Names
eukaryotic translation initiation factor 3, subunit 8, 110kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213463.1 → NP_998628.1  eukaryotic translation initiation factor 3 subunit C

    See identical proteins and their annotated locations for NP_998628.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057465
    UniProtKB/Swiss-Prot
    Q6PFQ2
    Related
    ENSDARP00000011344.9, ENSDART00000016791.11
    Conserved Domains (2) summary
    smart00753
    Location:777 → 862
    PAM; PCI/PINT associated module
    pfam05470
    Location:31 → 704
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    3944229..3962374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155999.5 → XP_005156056.1  eukaryotic translation initiation factor 3 subunit C isoform X1

    UniProtKB/TrEMBL
    A0A8M2B2W0
    Conserved Domains (3) summary
    smart00753
    Location:777 → 862
    PAM; PCI/PINT associated module
    pfam05091
    Location:888 → 939
    eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
    pfam05470
    Location:31 → 704
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFQ2.1 GenPept UniProtKB/Swiss-Prot:Q6PFQ2

Gene LinkOut

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