slc43a1a solute carrier family 43 member 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc43a1aprovided by ZNC
Official Full Name: solute carrier family 43 member 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6327
See related: Ensembl:ENSDARG00000037393 AllianceGenome:ZFIN:ZDB-GENE-030131-6327
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lat3a; fi47a12; slc43a1; zgc:55850; wu:fi47a12
Summary: Predicted to enable L-amino acid transmembrane transporter activity and neutral L-amino acid transmembrane transporter activity. Acts upstream of or within podocyte development. Predicted to be located in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; axis; digestive system; intermediate cell mass of mesoderm; and interrenal primordium. Orthologous to human SLC43A1 (solute carrier family 43 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (22076596..22098011)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (21779351..21800766)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LAT3 may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton [LAT3].
Title: Amino acid transporter LAT3 is required for podocyte development and function.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in neutral amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within podocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 43 member 1a

Names: solute carrier family 43 (amino acid system L transporter), member 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001327986.1 → NP_001314915.1 solute carrier family 43 member 1a

Status: VALIDATED

Source sequence(s)

CU062437

UniProtKB/TrEMBL

A0A8M1P9P9, F2Z4V7

Related

ENSDARP00000096925.4, ENSDART00000106147.6

Conserved Domains (2) summary

cd06174
Location:77 → 220

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:77 → 460

MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

22076596..22098011

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394904.1 Reference GRCz11 ALT_DRER_TU_1

Range

258615..280030

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_199897.1: Suppressed sequence

Description

NM_199897.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.