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ficd FIC domain protein adenylyltransferase [ Danio rerio (zebrafish) ]

Gene ID: 334648, updated on 4-Jan-2025

Summary

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Official Symbol
ficdprovided by ZNC
Official Full Name
FIC domain protein adenylyltransferaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6588
See related
Ensembl:ENSDARG00000035595 AllianceGenome:ZFIN:ZDB-GENE-030131-6588
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hype; fk44h08; wu:fk44h08; zgc:110336; si:ch211-191d15.5
Summary
Predicted to enable AMPylase activity. Predicted to be involved in protein adenylylation. Predicted to be located in membrane. Orthologous to human FICD (FIC domain protein adenylyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ficd in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (20485624..20491209, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (19982035..19987419, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly enzyme a Neighboring gene spliceosome associated factor 3, U4/U6 recycling protein Neighboring gene chemerin-like receptor 1 Neighboring gene chemokine-like receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Trede NS, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17416673, Free PMC Article
  2. Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. Weh E, et al. PLoS One, 2017. PMID 28926587, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables AMPylase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMPylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein adenylylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein adenylyltransferase FICD
Names
AMPylator FICD
FIC domain containing
FIC domain-containing protein
Huntingtin interacting protein E
adenosine monophosphate-protein transferase FICD
NP_001017794.1
XP_005165169.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017794.2 → NP_001017794.1  protein adenylyltransferase FICD

    See identical proteins and their annotated locations for NP_001017794.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092885
    UniProtKB/Swiss-Prot
    Q6ZM51
    Related
    ENSDARP00000145045.1, ENSDART00000183051.1
    Conserved Domains (5) summary
    COG3177
    Location:191 → 401
    COG3177; Fic family protein [Transcription]
    sd00006
    Location:96 → 124
    TPR; TPR repeat [structural motif]
    pfam02661
    Location:275 → 371
    Fic; Fic/DOC family
    pfam13414
    Location:95 → 161
    TPR_11; TPR repeat
    cl14812
    Location:80 → 133
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    20485624..20491209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165112.5 → XP_005165169.1  protein adenylyltransferase FICD isoform X1

    See identical proteins and their annotated locations for XP_005165169.1

    UniProtKB/Swiss-Prot
    Q6ZM51
    Related
    ENSDARP00000123219.1, ENSDART00000144232.3
    Conserved Domains (5) summary
    COG3177
    Location:191 → 401
    COG3177; Fic family protein [Transcription]
    sd00006
    Location:96 → 124
    TPR; TPR repeat [structural motif]
    pfam02661
    Location:275 → 371
    Fic; Fic/DOC family
    pfam13414
    Location:95 → 161
    TPR_11; TPR repeat
    cl14812
    Location:80 → 133
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZM51.1 GenPept UniProtKB/Swiss-Prot:Q6ZM51

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