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rapgef6 Rap guanine nucleotide exchange factor (GEF) 6 [ Danio rerio (zebrafish) ]

Gene ID: 335032, updated on 14-Nov-2024

Summary

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Official Symbol
rapgef6provided by ZNC
Official Full Name
Rap guanine nucleotide exchange factor (GEF) 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6972
See related
AllianceGenome:ZFIN:ZDB-GENE-030131-6972
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa12b02
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within proteolysis and small GTPase-mediated signal transduction. Predicted to be located in cytoplasm and membrane. Predicted to be active in apical plasma membrane and endocytic vesicle. Orthologous to human RAPGEF6 (Rap guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See rapgef6 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (45043418..45073740, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (45019098..45049600, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 4 Neighboring gene ring finger protein 121 Neighboring gene follistatin-like 4 Neighboring gene si:ch73-269m14.2 Neighboring gene voltage-dependent anion channel 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rap guanine nucleotide exchange factor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    45043418..45073740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353005.2 → XP_017208494.2  rap guanine nucleotide exchange factor 6

    UniProtKB/TrEMBL
    A0A8M6Z3X1
    Conserved Domains (6) summary
    smart00100
    Location:290 → 405
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00147
    Location:866 → 1102
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:421 → 534
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00992
    Location:538 → 618
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00047
    Location:49 → 154
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cl00155
    Location:759 → 843
    UBQ; Ubiquitin-like proteins
Nucleotide Protein Strain
Heading Accession and Version

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