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mak male germ cell-associated kinase [ Danio rerio (zebrafish) ]

Gene ID: 335339, updated on 2-Nov-2024

Summary

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Official Symbol
makprovided by ZNC
Official Full Name
male germ cell-associated kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7279
See related
Ensembl:ENSDARG00000059287 AllianceGenome:ZFIN:ZDB-GENE-030131-7279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Ick; fj04c02; zgc:56603; wu:fj04c02
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within motile cilium assembly. Predicted to be active in cilium; cytoplasm; and nucleus. Is expressed in Kupffer's vesicle; retina; and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Orthologous to human MAK (male germ cell associated kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mak in Genome Data Viewer
Location:
chromosome: 24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (8740477..8777570, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (8601725..8637202, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member B3 Neighboring gene transcription factor AP-2 alpha Neighboring gene transmembrane protein 14Ca Neighboring gene uncharacterized LOC110438349 Neighboring gene glial cells missing transcription factor 2 Neighboring gene synaptonemal complex protein 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors. Chiang HJ, et al. Dis Model Mech, 2024 Jul 1. PMID 38813692, Free PMC Article
  2. Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa. Tucker BA, et al. Gene Ther, 2022 May. PMID 34518651, Free PMC Article
  3. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
  4. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors.
    Title: Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase MAK
Names
intestinal cell kinase
NP_956240.1
XP_005162620.1
XP_005162621.1
XP_009295564.1
XP_009295566.1
XP_021325788.1
XP_068073134.1
XP_068073135.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199946.1 → NP_956240.1  serine/threonine-protein kinase MAK

    See identical proteins and their annotated locations for NP_956240.1

    Status: PROVISIONAL

    Source sequence(s)
    BC052126
    UniProtKB/TrEMBL
    Q7ZTX0
    Related
    ENSDARP00000076797.4, ENSDART00000082362.6
    Conserved Domains (2) summary
    smart00220
    Location:4 → 285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4 → 285
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    8740477..8777570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470113.2 → XP_021325788.1  serine/threonine-protein kinase MAK isoform X5

    UniProtKB/TrEMBL
    A0A8M9PFV2
    Conserved Domains (1) summary
    cd07830
    Location:4 → 285
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  2. XM_005162564.5 → XP_005162621.1  serine/threonine-protein kinase MAK isoform X3

    UniProtKB/TrEMBL
    A0A8M2B9R2
    Conserved Domains (2) summary
    smart00220
    Location:4 → 285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4 → 285
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  3. XM_009297291.4 → XP_009295566.1  serine/threonine-protein kinase MAK isoform X4

    UniProtKB/TrEMBL
    A0A8M3ANF8
    Conserved Domains (2) summary
    smart00220
    Location:4 → 284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4 → 284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  4. XM_005162563.5 → XP_005162620.1  serine/threonine-protein kinase MAK isoform X2

    UniProtKB/TrEMBL
    A0A286Y937, A0A8M2B9F1
    Related
    ENSDARP00000143675.1, ENSDART00000177400.2
    Conserved Domains (2) summary
    smart00220
    Location:4 → 284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4 → 284
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  5. XM_009297289.4 → XP_009295564.1  serine/threonine-protein kinase MAK isoform X1

    UniProtKB/TrEMBL
    A0A8M3AVX2, F1QUT2
    Conserved Domains (2) summary
    smart00220
    Location:4 → 285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07830
    Location:4 → 285
    STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

  6. XM_068217034.1 → XP_068073135.1  serine/threonine-protein kinase MAK isoform X4

  7. XM_068217033.1 → XP_068073134.1  serine/threonine-protein kinase MAK isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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