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gngt2a guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a [ Danio rerio (zebrafish) ]

Gene ID: 335655, updated on 2-Nov-2024

Summary

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Official Symbol
gngt2aprovided by ZNC
Official Full Name
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7595
See related
Ensembl:ENSDARG00000010680 AllianceGenome:ZFIN:ZDB-GENE-030131-7595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gngt2; id:ibd1139; wu:fk53d05
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in myotome; pineal complex; visual system; and yolk syncytial layer. Orthologous to human GNGT2 (G protein subunit gamma transducin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gngt2a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (23092760..23096135)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (22962212..22965587)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 2 (SID blood group), tandelm duplication 2 Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 2 (SID blood group), tandem duplication 1 Neighboring gene uncharacterized LOC137490046 Neighboring gene collagen, type I, alpha 1a Neighboring gene protein phosphatase 1, regulatory subunit 9Ba

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of the G protein gammaT1 subunit during zebrafish development. Chen H, et al. Gene Expr Patterns, 2007 Apr. PMID 17306630, Free PMC Article
  2. Identification of differentially expressed genes during development of the zebrafish pineal complex using RNA sequencing. Khuansuwan S, et al. Dev Biol, 2014 Nov 1. PMID 25173875, Free PMC Article
  3. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. Brockerhoff SE, et al. J Neurosci, 2003 Jan 15. PMID 12533607, Free PMC Article
  4. Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation. Lagman D, et al. PLoS One, 2015. PMID 25806532, Free PMC Article
  5. Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Mulligan T, et al. Cell Signal, 2010 Feb. PMID 19786091, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta-subunit binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2a
Names
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
transducin gamma (cone)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302500.1 → NP_001289429.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2a

    See identical proteins and their annotated locations for NP_001289429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT573473, EH451823, EH455226, EH456883
    UniProtKB/TrEMBL
    A0A8M1P740, Q6PBR4
    Related
    ENSDARP00000014423.6, ENSDART00000024136.7
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

  2. NM_001302501.1 → NP_001289430.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2a

    See identical proteins and their annotated locations for NP_001289430.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT573473, EH451823, EH456883
    UniProtKB/TrEMBL
    A0A8M1P740, Q6PBR4
    Related
    ENSDARP00000117694.1, ENSDART00000142884.2
    Conserved Domains (1) summary
    smart00224
    Location:8 → 69
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    23092760..23096135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394530.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    160532..163901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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