irf2bp2a interferon regulatory factor 2 binding protein 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: irf2bp2aprovided by ZNC
Official Full Name: interferon regulatory factor 2 binding protein 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7809
See related: AllianceGenome:ZFIN:ZDB-GENE-030131-7809
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IRF2BP2; fj35c12; irf2bp2b; zgc:56251; wu:fj35c12; CH1073-404G22.1
Summary: Predicted to enable transcription corepressor activity. Acts upstream of or within liver development and neutrophil differentiation. Predicted to be active in nucleus. Is expressed in several structures, including midbrain neural keel; musculature system; nervous system; periderm; and presumptive diencephalon. Human ortholog(s) of this gene implicated in common variable immunodeficiency 14. Orthologous to human IRF2BP2 (interferon regulatory factor 2 binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (49442073..49444636, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (49151395..49153958, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Irf2bp2a regulates liver development via stabilizing P53 protein in zebrafish.
Title: Irf2bp2a regulates liver development via stabilizing P53 protein in zebrafish.
Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish.
Title: Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interferon regulatory factor 2-binding protein 2-A

Names: IRF-2-binding protein 2-A; IRF-2-binding protein 2-B; IRF-2BP2-A; IRF-2BP2-B; interferon regulatory factor 2 binding protein 2; interferon regulatory factor 2-binding protein 2-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199981.1 → NP_956275.1 interferon regulatory factor 2-binding protein 2-A

See identical proteins and their annotated locations for NP_956275.1

Status: PROVISIONAL

Source sequence(s)

BC046025

UniProtKB/Swiss-Prot

B8JMF1, Q6NZT6, Q7ZV30

Conserved Domains (1) summary

pfam11261
Location:10 → 61

IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger