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got2b glutamic-oxaloacetic transaminase 2b, mitochondrial [ Danio rerio (zebrafish) ]

Gene ID: 335974, updated on 9-Dec-2024

Summary

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Official Symbol
got2bprovided by ZNC
Official Full Name
glutamic-oxaloacetic transaminase 2b, mitochondrialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7917
See related
Ensembl:ENSDARG00000005840 AllianceGenome:ZFIN:ZDB-GENE-030131-7917
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj40h07; zgc:56425; wu:fj40h07
Summary
Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate catabolic process. Predicted to act upstream of or within amino acid metabolic process and biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See got2b in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (51774564..51793881)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (51499494..51518811)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene liver-expressed antimicrobial peptide 2 Neighboring gene bone morphogenetic protein 15 Neighboring gene uncharacterized LOC137496218 Neighboring gene solute carrier family 38 member 7 Neighboring gene si:ch211-122f10.4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. Wu X, et al. Int J Mol Sci, 2022 Apr 11. PMID 35457018, Free PMC Article
  2. Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2019 Nov 11. PMID 31712630, Free PMC Article
  3. UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Zhang J, et al. Environ Pollut, 2020 Nov. PMID 32798906
  4. Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. Gebriel M, et al. J Neurosci Res, 2014 Jan. PMID 24123299
  5. Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish. Lam SH, et al. PLoS One, 2011. PMID 22194820, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-aspartate:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aspartate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutamic-oxaloacetic transaminase 2b, mitochondrial
Names
glutamate oxaloacetate transaminase 2
glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)
NP_956283.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199989.1 → NP_956283.1  glutamic-oxaloacetic transaminase 2b, mitochondrial

    See identical proteins and their annotated locations for NP_956283.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049435
    UniProtKB/TrEMBL
    Q7ZWF5
    Related
    ENSDARP00000024560.5, ENSDART00000007767.6
    Conserved Domains (2) summary
    PLN02397
    Location:26 → 428
    PLN02397; aspartate transaminase
    pfam00155
    Location:55 → 423
    Aminotran_1_2; Aminotransferase class I and II

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    51774564..51793881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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