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thy1 Thy-1 cell surface antigen [ Danio rerio (zebrafish) ]

Gene ID: 336617, updated on 14-Nov-2024

Summary

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Official Symbol
thy1provided by ZNC
Official Full Name
Thy-1 cell surface antigenprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8561
See related
Ensembl:ENSDARG00000035018 AllianceGenome:ZFIN:ZDB-GENE-030131-8561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb15c03; wu:fb18g05; zgc:123140
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in integrin-mediated signaling pathway and positive regulation of focal adhesion assembly. Predicted to act upstream of or within cell adhesion and regulation of cell migration. Predicted to be located in plasma membrane. Predicted to be active in dendrite; external side of plasma membrane; and membrane raft. Is expressed in eye. Orthologous to human THY1 (Thy-1 cell surface antigen). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See thy1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (29794040..29803293)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (29193887..29203140)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene BarH-like homeobox 1a Neighboring gene cilia and flagella associated protein 77 Neighboring gene si:ch211-215c18.3 Neighboring gene upstream transcription factor 1, like Neighboring gene F11 receptor, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons. Deininger SO, et al. Mol Cell Neurosci, 2003 Apr. PMID 12727449
  2. Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis. Liu C, et al. Dev Cell, 2022 May 23. PMID 35512701
  3. Evolutionary analysis and expression of teleost Thy-1. Reuter A, et al. Zebrafish, 2004. PMID 18248231
  4. Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Liu J, et al. Nat Commun, 2016 Oct 7. PMID 27713410, Free PMC Article
  5. Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. Veth KN, et al. PLoS Genet, 2011 Feb. PMID 21379331, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC123140

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thy-1 membrane glycoprotein
NP_001300699.1
XP_021331692.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313770.1 → NP_001300699.1  thy-1 membrane glycoprotein precursor

    Status: VALIDATED

    Source sequence(s)
    EH526245, EH546814, EH577813
    UniProtKB/TrEMBL
    A0A8M1P731, A2BFD8
    Related
    ENSDARP00000045409.6, ENSDART00000045410.7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    29794040..29803293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476017.2 → XP_021331692.2  thy-1 membrane glycoprotein isoform X1

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394581.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    153342..155207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395239.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    151074..160327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198065.1: Suppressed sequence

    Description
    NM_198065.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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