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gsnb gelsolin b [ Danio rerio (zebrafish) ]

Gene ID: 336623, updated on 2-Nov-2024

Summary

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Official Symbol
gsnbprovided by ZNC
Official Full Name
gelsolin bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8567
See related
Ensembl:ENSDARG00000045262 AllianceGenome:ZFIN:ZDB-GENE-030131-8567
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gsnl; gsnl2; wu:fa92a06; wu:fb15e01; wu:fc14a07; wu:fc28h09
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within actin filament capping and cell projection organization. Predicted to be active in actin cytoskeleton; cytoplasm; and extracellular space. Is expressed in several structures, including epidermis; hatching gland; otic vesicle; periderm; and sensory system. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See gsnb in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (63294865..63302916, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (62601168..62609549, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene tectorin alpha Neighboring gene tubulin folding cofactor E-like b Neighboring gene transcription termination factor 1, tandem duplicate 6 Neighboring gene transcription termination factor 1, tandem duplicate 5 Neighboring gene transcription termination factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene (scinla) encodes the major corneal crystallin. Jia S, et al. FASEB J, 2007 Oct. PMID 17548429, Free PMC Article
  2. Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. Lou SS, et al. J Cell Biol, 2015 Apr 27. PMID 25918227, Free PMC Article
  3. Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression. Luckner B, et al. Ecotoxicol Environ Saf, 2023 Nov 1. PMID 37844410
  4. SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Fazio M, et al. Elife, 2021 Feb 2. PMID 33527896, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gelsolin b
Names
gelsolin, like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089344.1 → NP_001082813.1  gelsolin b

    See identical proteins and their annotated locations for NP_001082813.1

    Status: PROVISIONAL

    Source sequence(s)
    BC135025
    UniProtKB/TrEMBL
    A4IGC2
    Related
    ENSDARP00000047109.6, ENSDART00000047110.7
    Conserved Domains (6) summary
    cd11288
    Location:508 → 597
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:133 → 216
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:7 → 119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:612 → 710
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:245 → 341
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:386 → 486
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    63294865..63302916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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