icn ictacalcin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: icnprovided by ZNC
Official Full Name: ictacalcinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8599
See related: Ensembl:ENSDARG00000009978 AllianceGenome:ZFIN:ZDB-GENE-030131-8599
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa91d07; s100a4a; mg:cb02f02; wu:fa91d07
Summary: Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; fin; hematopoietic system; integument; and sensory system. Orthologous to several human genes including S100A4 (S100 calcium binding protein A4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (23431180..23432552)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (23516148..23517520)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ictacalcin is expressed in skin during zebrafish embryogenesis
Title: Skin-specific expression of ictacalcin, a homolog of the S100 genes, during zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ictacalcin

Names: S100 calcium binding protein A4a; calvasculin; metastasin; s100i1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212761.2 → NP_997926.1 ictacalcin

See identical proteins and their annotated locations for NP_997926.1

Status: VALIDATED

Source sequence(s)

BC107522, CR533578

UniProtKB/TrEMBL

F6NZN2, Q3B7P2, Q6XG62

Related

ENSDARP00000020595.7, ENSDART00000004679.8

Conserved Domains (2) summary

cd00213
Location:4 → 91

S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...

pfam13499
Location:29 → 80

EF-hand_7; EF-hand domain pair