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atp5f1c ATP synthase F1 subunit gamma [ Danio rerio (zebrafish) ]

Gene ID: 336957, updated on 4-Jan-2025

Summary

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Official Symbol
atp5f1cprovided by ZNC
Official Full Name
ATP synthase F1 subunit gammaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8901
See related
Ensembl:ENSDARG00000045514 AllianceGenome:ZFIN:ZDB-GENE-030131-8901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
atp5c1; zgc:73209; wu:fk34c05
Summary
Predicted to enable proton-transporting ATP synthase activity, rotational mechanism. Predicted to act upstream of or within proton motive force-driven ATP synthesis and proton transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of proton-transporting ATP synthase complex, catalytic core F(1). Orthologous to human ATP5F1C (ATP synthase F1 subunit gamma). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See atp5f1c in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (25173218..25181582, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (25184020..25192384, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene GATA binding protein 3 Neighboring gene TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene uncharacterized LOC137491552 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of Lithium and 2,4-Dichlorophenol on Zebrafish: Circadian Rhythm Disorder and Molecular Effects. Xiao B, et al. Zebrafish, 2017 Jun. PMID 28318412
  2. Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism. Chen D, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30916346, Free PMC Article
  3. Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. Lee JY, et al. Sci Total Environ, 2021 Jun 1. PMID 33548715
  4. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
  5. A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Ayobahan SU, et al. Sci Rep, 2019 Apr 29. PMID 31036921, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase subunit gamma, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
NP_001315479.1
NP_001315480.1
NP_956335.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328550.1 → NP_001315479.1  ATP synthase subunit gamma, mitochondrial isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    BX640594, EH461834, EH484827, EH528823
    UniProtKB/TrEMBL
    A0A8M1P9B7, Q5RH26
    Conserved Domains (1) summary
    TIGR01146
    Location:21 → 292
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

  2. NM_001328551.1 → NP_001315480.1  ATP synthase subunit gamma, mitochondrial isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BX640594, EH447408, EH461834, EH484827, EH528823
    UniProtKB/TrEMBL
    A0A8M1P526
    Conserved Domains (1) summary
    TIGR01146
    Location:21 → 292
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

  3. NM_200041.2 → NP_956335.2  ATP synthase subunit gamma, mitochondrial isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    BX640594
    UniProtKB/TrEMBL
    A0A8M1P9B7, Q5RH26
    Related
    ENSDARP00000066929.6, ENSDART00000066930.7
    Conserved Domains (1) summary
    TIGR01146
    Location:21 → 292
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    25173218..25181582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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