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prrx1b paired related homeobox 1b [ Danio rerio (zebrafish) ]

Gene ID: 337089, updated on 14-Nov-2024

Summary

Official Symbol
prrx1bprovided by ZNC
Official Full Name
paired related homeobox 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9033
See related
Ensembl:ENSDARG00000042027 AllianceGenome:ZFIN:ZDB-GENE-030131-9033
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa97b09; zgc:64199; wu:fa97b09; zgc:101095
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; cranial skeletal system development; and regulation of cardiac muscle cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including mesenchyme; pectoral fin bud; pectoral fin field; pharyngeal arch; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Orthologous to human PRRX1 (paired related homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See prrx1b in Genome Data Viewer
Location:
chromosome: 20
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (34511581..34521041)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (34608593..34618162)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase Neighboring gene uncharacterized LOC103909331 Neighboring gene golgin, rab6-interacting Neighboring gene phosphodiesterase 4D interacting protein Neighboring gene si:ch211-63o20.10

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General protein information

Preferred Names
paired mesoderm homeobox protein 1b
Names
phox1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200050.1NP_956344.1  paired mesoderm homeobox protein 1b

    See identical proteins and their annotated locations for NP_956344.1

    Status: PROVISIONAL

    Source sequence(s)
    BC064671
    UniProtKB/TrEMBL
    A0A8N7UZY4, Q6P295
    Related
    ENSDARP00000061587.4, ENSDART00000061588.6
    Conserved Domains (2) summary
    pfam00046
    Location:101152
    Homeobox; Homeobox domain
    pfam03826
    Location:220237
    OAR; OAR domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    34511581..34521041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352441.3XP_017207930.1  paired mesoderm homeobox protein 1b isoform X2

    UniProtKB/TrEMBL
    A0A8M6YUR5
  2. XM_005160643.5XP_005160700.1  paired mesoderm homeobox protein 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M2B7I0
    Related
    ENSDARP00000115613.1, ENSDART00000131637.2
    Conserved Domains (1) summary
    pfam00046
    Location:101152
    Homeobox; Homeobox domain