prrx1b paired related homeobox 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prrx1bprovided by ZNC
Official Full Name: paired related homeobox 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9033
See related: Ensembl:ENSDARG00000042027 AllianceGenome:ZFIN:ZDB-GENE-030131-9033
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa97b09; zgc:64199; wu:fa97b09; zgc:101095
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; cranial skeletal system development; and regulation of cardiac muscle cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including mesenchyme; pectoral fin bud; pectoral fin field; pharyngeal arch; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Orthologous to human PRRX1 (paired related homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (34511581..34521041)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (34608593..34618162)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration.
Title: Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration.
Prrx1b, a Prx-related homeobox protein, participates in the regulation of vmhc expression with other transcriptional factors.
Title: Promoter analysis of ventricular myosin heavy chain (vmhc) in zebrafish embryos.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: paired mesoderm homeobox protein 1b

Names: phox1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200050.1 → NP_956344.1 paired mesoderm homeobox protein 1b

See identical proteins and their annotated locations for NP_956344.1

Status: PROVISIONAL

Source sequence(s)

BC064671

UniProtKB/TrEMBL

A0A8N7UZY4, Q6P295

Related

ENSDARP00000061587.4, ENSDART00000061588.6

Conserved Domains (2) summary

pfam00046
Location:101 → 152

Homeobox; Homeobox domain

pfam03826
Location:220 → 237

OAR; OAR domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

34511581..34521041

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017352441.3 → XP_017207930.1 paired mesoderm homeobox protein 1b isoform X2

UniProtKB/TrEMBL

A0A8M6YUR5
XM_005160643.5 → XP_005160700.1 paired mesoderm homeobox protein 1b isoform X1

UniProtKB/TrEMBL

A0A8M2B7I0

Related

ENSDARP00000115613.1, ENSDART00000131637.2

Conserved Domains (1) summary

pfam00046
Location:101 → 152

Homeobox; Homeobox domain