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tsc1a TSC complex subunit 1a [ Danio rerio (zebrafish) ]

Gene ID: 337167, updated on 2-Nov-2024

Summary

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Official Symbol
tsc1aprovided by ZNC
Official Full Name
TSC complex subunit 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9111
See related
Ensembl:ENSDARG00000026048 AllianceGenome:ZFIN:ZDB-GENE-030131-9111
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa99f04; zgc:63657; wu:fa99f04
Summary
Acts upstream of or within several processes, including cilium assembly; determination of left/right symmetry; and regulation of TOR signaling. Located in Golgi apparatus. Is expressed in notochord; polster; pronephric duct; and somite. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See tsc1a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (29652468..29668982)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (29052295..29068818)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 1 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate 1b Neighboring gene sperm acrosome associated 9 Neighboring gene adenylate kinase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pronephros development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TSC1-TSC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TSC complex subunit 1a
Names
tuberous sclerosis 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200052.1 → NP_956346.1  TSC complex subunit 1a

    See identical proteins and their annotated locations for NP_956346.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055190
    UniProtKB/TrEMBL
    Q7SXZ2
    Related
    ENSDARP00000035073.5, ENSDART00000035400.6
    Conserved Domains (2) summary
    pfam04388
    Location:8 → 691
    Hamartin; Hamartin protein
    pfam10211
    Location:848 → 934
    Ax_dynein_light; Axonemal dynein light chain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    29652468..29668982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171795.5 → XP_005171852.1  TSC complex subunit 1a isoform X1

    See identical proteins and their annotated locations for XP_005171852.1

    UniProtKB/TrEMBL
    A0A2R8QHE1, A0A8M2BJK9
    Related
    ENSDARP00000153412.1, ENSDART00000184083.1
    Conserved Domains (2) summary
    pfam04388
    Location:8 → 700
    Hamartin; Hamartin protein
    pfam10211
    Location:857 → 943
    Ax_dynein_light; Axonemal dynein light chain

  2. XM_005171797.5 → XP_005171854.1  TSC complex subunit 1a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BJ51
    Conserved Domains (2) summary
    pfam04388
    Location:8 → 674
    Hamartin; Hamartin protein
    pfam10211
    Location:831 → 917
    Ax_dynein_light; Axonemal dynein light chain

  3. XM_005171796.5 → XP_005171853.1  TSC complex subunit 1a isoform X1

    See identical proteins and their annotated locations for XP_005171853.1

    UniProtKB/TrEMBL
    A0A2R8QHE1, A0A8M2BJK9
    Conserved Domains (2) summary
    pfam04388
    Location:8 → 700
    Hamartin; Hamartin protein
    pfam10211
    Location:857 → 943
    Ax_dynein_light; Axonemal dynein light chain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394581.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    12064..27018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395239.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    12053..26960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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