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sulf1 sulfatase 1 [ Danio rerio (zebrafish) ]

Gene ID: 337298, updated on 2-Nov-2024

Summary

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Official Symbol
sulf1provided by ZNC
Official Full Name
sulfatase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9242
See related
Ensembl:ENSDARG00000038428 AllianceGenome:ZFIN:ZDB-GENE-030131-9242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fk14e08
Summary
Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Acts upstream of or within with a positive effect on epithelial structure maintenance. Acts upstream of or within several processes, including neuromast deposition; regulation of myotome development; and vasculogenesis. Predicted to be located in Golgi stack. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; head; hypochord; and somite. Orthologous to human SULF1 (sulfatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See sulf1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (19518559..19587535)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (19374157..19443110)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Neighboring gene zgc:162928 Neighboring gene solute carrier organic anion transporter family member 5A1 Neighboring gene cysteine-serine-rich nuclear protein 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2. Gorsi B, et al. Dev Dyn, 2010 Dec. PMID 20981828
  2. Sulf1 modulates BMP signaling and is required for somite morphogenesis and development of the horizontal myoseptum. Meyers JR, et al. Dev Biol, 2013 Jun 15. PMID 23583585
  3. In vivo analysis of choroid plexus morphogenesis in zebrafish. García-Lecea M, et al. PLoS One, 2008 Sep 1. PMID 18769618, Free PMC Article
  4. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish. Schenk H, et al. Biomed Res Int, 2019. PMID 31428635, Free PMC Article
  5. Co-option of the PRDM14-CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Kawaguchi M, et al. Development, 2019 Jan 28. PMID 30630825

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish.
    Title: Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish.
  2. lack of SULF1 expression downregulates VEGFA-mediated arterial marker expression, confirming that Sulf1 mediates arterial specification by regulating VegfA165 activity.
    Title: The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity.
  3. Sulf1 triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors
    Title: Dynamics of sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring sulfatase 1.
  4. Data indicate that sulf1 plays a crucial role in modulating both BMP and FGF signaling.
    Title: Sulf1 modulates BMP signaling and is required for somite morphogenesis and development of the horizontal myoseptum.
  5. Zebrafish sulf1 and sulf2a are broadly expressed in the central nervous system (CNS) and non-neuronal tissue including heart, somite boundaries, olfactory system, and otic vesicle.
    Title: Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfuric ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood circulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect epithelial structure maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within_positive_effect epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glomerular basement membrane development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromast deposition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of developmental pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of myotome development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
extracellular sulfatase Sulf-1
Names
sulfatase FP1c
NP_001003846.1
XP_068073137.1
XP_068073138.1
XP_068073139.1
XP_068073140.1
XP_068073141.1
XP_068073142.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003846.2 → NP_001003846.1  extracellular sulfatase Sulf-1 precursor

    See identical proteins and their annotated locations for NP_001003846.1

    Status: VALIDATED

    Source sequence(s)
    CR382282, CR385071
    UniProtKB/TrEMBL
    A0A8M1N1N4, Q6EFA1
    Related
    ENSDARP00000056080.2, ENSDART00000056081.4
    Conserved Domains (4) summary
    COG3119
    Location:41 → 392
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:540 → 675
    DUF3740; Sulfatase protein
    cd16147
    Location:41 → 383
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:770 → 819
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    19518559..19587535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217039.1 → XP_068073140.1  extracellular sulfatase Sulf-1 isoform X3

    Related
    ENSDARP00000056079.3, ENSDART00000056080.6

  2. XM_068217040.1 → XP_068073141.1  extracellular sulfatase Sulf-1 isoform X4

    Related
    ENSDARP00000153504.1, ENSDART00000191042.1

  3. XM_068217041.1 → XP_068073142.1  extracellular sulfatase Sulf-1 isoform X5

    Related
    ENSDARP00000013515.7, ENSDART00000027022.8

  4. XM_068217038.1 → XP_068073139.1  extracellular sulfatase Sulf-1 isoform X2

  5. XM_068217036.1 → XP_068073137.1  extracellular sulfatase Sulf-1 isoform X1

    Related
    ENSDARP00000153732.1, ENSDART00000180782.1

  6. XM_068217037.1 → XP_068073138.1  extracellular sulfatase Sulf-1 isoform X1

Nucleotide Protein
Heading Accession and Version

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