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chia.4 chitinase, acidic.4 [ Danio rerio (zebrafish) ]

Gene ID: 337333, updated on 2-Nov-2024

Summary

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Official Symbol
chia.4provided by ZNC
Official Full Name
chitinase, acidic.4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9279
See related
Ensembl:ENSDARG00000008541 AllianceGenome:ZFIN:ZDB-GENE-030131-9279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CHIA; chioIIa; zgc:63792; wu:fa55g10
Summary
Predicted to enable chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See chia.4 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (17926279..17933143)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (17999936..18006800)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene calcium-independent phospholipase A2-gamma-like Neighboring gene neurofascin homolog (chicken) b Neighboring gene uncharacterized LOC137489113 Neighboring gene chitinase, acidic.5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Spatial and temporal expression patterns of chitinase genes in developing zebrafish embryos. Koch BE, et al. Gene Expr Patterns, 2014 Mar. PMID 24418193
  2. Global proteomics analysis of testis and ovary in adult zebrafish (Danio rerio). Groh KJ, et al. Fish Physiol Biochem, 2011 Sep. PMID 21229308, Free PMC Article
  3. Rearing Zebrafish on Black Soldier Fly (Hermetia illucens): Biometric, Histological, Spectroscopic, Biochemical, and Molecular Implications. Vargas A, et al. Zebrafish, 2018 Aug. PMID 29589997
  4. Partial Dietary Inclusion of Hermetia illucens (Black Soldier Fly) Full-Fat Prepupae in Zebrafish Feed: Biometric, Histological, Biochemical, and Molecular Implications. Zarantoniello M, et al. Zebrafish, 2018 Oct. PMID 29912648
  5. Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Xu Y, et al. Front Endocrinol (Lausanne), 2022. PMID 35547009, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC63792

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chitinase, acidic.4
Names
chia4
eosinophil chemotactic cytokine
NP_956740.1
XP_068072794.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200446.1 → NP_956740.1  chitinase, acidic.4 precursor

    See identical proteins and their annotated locations for NP_956740.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054942
    UniProtKB/TrEMBL
    Q7SYA8
    Related
    ENSDARP00000005298.5, ENSDART00000012540.6
    Conserved Domains (3) summary
    cd02872
    Location:25 → 381
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:425 → 473
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:22 → 363
    Glyco_18; Glyco_18 domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    17926279..17933143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216693.1 → XP_068072794.1  chitinase, acidic.4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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