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dennd6b DENN/MADD domain containing 6B [ Danio rerio (zebrafish) ]

Gene ID: 337436, updated on 2-Nov-2024

Summary

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Official Symbol
dennd6bprovided by ZNC
Official Full Name
DENN/MADD domain containing 6Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9382
See related
Ensembl:ENSDARG00000011605 AllianceGenome:ZFIN:ZDB-GENE-030131-9382
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fam116b; fj67e07; zgc:55619; wu:fj67e07
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in recycling endosome. Is expressed in central nervous system; cranial ganglion; retina; telencephalon; and yolk syncytial layer. Orthologous to human DENND6B (DENN domain containing 6B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See dennd6b in Genome Data Viewer
Location:
chromosome: 4
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20071128..20081659, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (20082149..20092720, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene zmp:0000000938 Neighboring gene GRIP and coiled-coil domain containing 1 Neighboring gene protein phosphatase 6, regulatory subunit 2a Neighboring gene coiled-coil domain containing 146 Neighboring gene FAM3 metabolism regulating signaling molecule C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Vejnar CE, et al. Genome Res, 2019 Jul. PMID 31227602, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein DENND6B
Names
family with sequence similarity 116, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200065.1 → NP_956359.1  protein DENND6B

    See identical proteins and their annotated locations for NP_956359.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044201
    UniProtKB/TrEMBL
    Q803T4
    Related
    ENSDARP00000008404.7, ENSDART00000024647.8
    Conserved Domains (2) summary
    pfam08616
    Location:242 → 348
    SPA; Stabilization of polarity axis
    cl11519
    Location:143 → 293
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    20071128..20081659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164716.5 → XP_005164773.1  protein DENND6B isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBU9
    Conserved Domains (2) summary
    pfam08616
    Location:242 → 348
    SPA; Stabilization of polarity axis
    cl11519
    Location:143 → 293
    DENN; DENN (AEX-3) domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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