mars1 methionyl-tRNA synthetase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mars1provided by ZNC
Official Full Name: methionyl-tRNA synthetase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030219-83
See related: Ensembl:ENSDARG00000034396 AllianceGenome:ZFIN:ZDB-GENE-030219-83
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mars; metrs; zgc:66122; id:ibd5106
Summary: Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytosol. Is expressed in several structures, including brain; digestive system; immature eye; pectoral fin bud; and swim bladder. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (58921240..58975022, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (58927009..58980776, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fc02h02.x1 (e-PCR)
- UniSTS:192086

z99031 (e-PCR), detects polymorphism
- UniSTS:238713

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables methionine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methionyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methionyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: methionine--tRNA ligase, cytoplasmic

Names: methionine-tRNA synthetase

NP_956370.2

EC 6.1.1.10

XP_068077760.1

EC 6.1.1.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.