bmper BMP binding endothelial regulator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmperprovided by ZNC
Official Full Name: BMP binding endothelial regulatorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030219-146
See related: Ensembl:ENSDARG00000101980 AllianceGenome:ZFIN:ZDB-GENE-030219-146
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cvl2; id:ibd5071
Summary: Enables extracellular matrix binding activity. Acts upstream of or within several processes, including neural crest formation; otic placode formation; and regulation of BMP signaling pathway. Located in extracellular matrix and extracellular space. Is expressed in several structures, including head; hematopoietic system; mesoderm; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (7154298..7195677)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (7213112..7278331)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that in endothelial cells, bone morphogenetic protein endothelial precursor-derived regulator (BMPER) and twisted gastrulation protein homolog 1 (TWSG1) are necessary for regular Notch signaling activity.
Title: Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial-venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells.
The NMR structure of the Danio rerio CV2 VWC1 domain in its unbound state shows the key features for high affinity binding to BMP-2 are a pre-oriented peptide loop.
Title: The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed.
Crossveinless 2 functions in a positive-feedback loop to locally enhance BMP activity and is required for neural crest fate determination.
Title: A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border.
LRP1 acts as an endocytic receptor for Bmper and a coreceptor of Bmp4 to mediate the endocytosis of the Bmper/Bmp4 signaling complex.
Title: LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.
Binding of CV2 to Chordin promotes BMP-2 signaling.
Title: Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin activity.
Initial crystallographic analysis suggests that a complete binary complex consisting of one BMP2 dimer bound to two crossveinless 2 (CV2) von Willebrand type C (VWC1) domains is present in the asymmetric unit.
Title: Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2.
The structure of the complex between CV-2 Von Willebrand factor type C (VWC) domain 1 and BMP-2, is reported.
Title: Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding.
Bmper is a conserved regulator of hematopoietic and vascular development in zebrafish.
Title: BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish.
Cvl2 was identified as an essential pro-bone morphogenetic protein factor during zebrafish embryogenesis.
Title: Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in blood vessel development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otic placode formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BMP-binding endothelial regulator protein

Names: crossveinless 2; cv2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020487.2 → NP_001018323.2 BMP-binding endothelial regulator protein precursor

See identical proteins and their annotated locations for NP_001018323.2

Status: PROVISIONAL

Source sequence(s)

BC146642

UniProtKB/TrEMBL

A6H8K2, Q5D734

Related

ENSDARP00000134708.1, ENSDART00000168830.2

Conserved Domains (5) summary

pfam00093
Location:152 → 210

VWC; von Willebrand factor type C domain

pfam00094
Location:348 → 490

VWD; von Willebrand factor type D domain

pfam01826
Location:612 → 665

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:539 → 607

C8; C8 domain

cl17735
Location:285 → 341

VWC; von Willebrand factor type C domain