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impdh1b IMP (inosine 5'-monophosphate) dehydrogenase 1b [ Danio rerio (zebrafish) ]

Gene ID: 338306, updated on 2-Nov-2024

Summary

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Official Symbol
impdh1bprovided by ZNC
Official Full Name
IMP (inosine 5'-monophosphate) dehydrogenase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030219-206
See related
Ensembl:ENSDARG00000029524 AllianceGenome:ZFIN:ZDB-GENE-030219-206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
D3; IMPDH1; IMPD 1b; IMPDH 1b; id:ibd5035; wu:fa09h11; wu:fa99c03; zgc:113446; si:dkey-31f5.7
Summary
Predicted to enable IMP dehydrogenase activity. Predicted to be involved in GTP biosynthetic process. Predicted to act upstream of or within purine nucleotide biosynthetic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; heart; nervous system; notochord; and pigment cell. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See impdh1b in Genome Data Viewer
Location:
chromosome: 4
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18960850..18985481)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18971603..18996505)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) Neighboring gene RAP1B, member of RAS oncogene family Neighboring gene proline rich transmembrane protein 4b Neighboring gene leptin b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. IMPDH forms the cytoophidium in zebrafish. Keppeke GD, et al. Dev Biol, 2021 Oct. PMID 34048735
  2. Mycophenolic Acid-Induced Developmental Defects in Zebrafish Embryos. Jiang LL, et al. Int J Toxicol, 2016 Nov. PMID 27694306
  3. A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells. Cleghorn WM, et al. J Biol Chem, 2022 Jan. PMID 34813793, Free PMC Article
  4. Integrative analysis of circadian transcriptome and metabolic network reveals the role of de novo purine synthesis in circadian control of cell cycle. Li Y, et al. PLoS Comput Biol, 2015 Feb. PMID 25714999, Free PMC Article
  5. Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Driessen M, et al. Toxicol Lett, 2014 Oct 1. PMID 25064622

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IMPDH forms the cytoophidium in zebrafish.
    Title: IMPDH forms the cytoophidium in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables IMP dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IMP dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inosine-5'-monophosphate dehydrogenase 1b
Names
IMP (inosine monophosphate) dehydrogenase 1
inosine 5'-phosphate dehydrogenase 1b
NP_001014391.1
XP_005164774.1
XP_005164775.1
XP_017210441.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014369.2 → NP_001014391.1  inosine-5'-monophosphate dehydrogenase 1b

    See identical proteins and their annotated locations for NP_001014391.1

    Status: VALIDATED

    Source sequence(s)
    BX649534, CT657866, DN896992, EH434249
    UniProtKB/Swiss-Prot
    Q5RGV1
    Related
    ENSDARP00000066974.4, ENSDART00000066975.6
    Conserved Domains (3) summary
    cd00381
    Location:29 → 493
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:115 → 230
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:16 → 510
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    18960850..18985481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164717.5 → XP_005164774.1  inosine-5'-monophosphate dehydrogenase 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M2BC24
    Conserved Domains (3) summary
    cd00381
    Location:118 → 582
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:204 → 319
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:104 → 599
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

  2. XM_005164718.5 → XP_005164775.1  inosine-5'-monophosphate dehydrogenase 1b isoform X2

    UniProtKB/TrEMBL
    A0A8M2BBW1
    Conserved Domains (3) summary
    cd00381
    Location:93 → 557
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:179 → 294
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:80 → 574
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

  3. XM_017354952.3 → XP_017210441.1  inosine-5'-monophosphate dehydrogenase 1b isoform X3

    UniProtKB/TrEMBL
    A0A8M6YXW5, Q5RGV0
    Related
    ENSDARP00000066972.4, ENSDART00000066973.5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RGV1.1 GenPept UniProtKB/Swiss-Prot:Q5RGV1

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