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Tmem241 transmembrane protein 241 [ Mus musculus (house mouse) ]

Gene ID: 338363, updated on 17-Aug-2024

Summary

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Official Symbol
Tmem241provided by MGI
Official Full Name
transmembrane protein 241provided by MGI
Primary source
MGI:MGI:2442435
See related
Ensembl:ENSMUSG00000049411 AllianceGenome:MGI:2442435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030446N20Rik
Summary
Predicted to enable antiporter activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human TMEM241 (transmembrane protein 241). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Tmem241 in Genome Data Viewer
Location:
18 A1; 18 5.98 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12113193..12254604, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (11980119..12121570, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43817 Neighboring gene CDK5 and Abl enzyme substrate 1 Neighboring gene microRNA 1901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12094438-12094547 Neighboring gene predicted gene, 41666 Neighboring gene STARR-seq mESC enhancer starr_43825 Neighboring gene STARR-seq mESC enhancer starr_43827 Neighboring gene STARR-seq mESC enhancer starr_43828 Neighboring gene STARR-seq mESC enhancer starr_43830 Neighboring gene STARR-positive B cell enhancer ABC_E4239 Neighboring gene predicted gene, 41667 Neighboring gene RIO kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. Liu N, et al. Nat Commun, 2022 Aug 11. PMID 35953472, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
    Title: TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
  2. Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
    Title: Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-N-acetylglucosamine transporter TMEM241; transmembrane protein 241
Names
transmembrane protein C18orf45 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289666.1 → NP_001276595.1  UDP-N-acetylglucosamine transporter TMEM241 isoform 1

    See identical proteins and their annotated locations for NP_001276595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK038472, AK051727
    Consensus CDS
    CCDS84358.1
    UniProtKB/Swiss-Prot
    Q3UME2, Q8BQ16, Q8CAM4, Q8CAM9, Q8CD42
    UniProtKB/TrEMBL
    B2RPV5
    Related
    ENSMUSP00000147687.2, ENSMUST00000209859.2
    Conserved Domains (1) summary
    COG5070
    Location:10 → 193
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  2. NM_001289667.1 → NP_001276596.1  UDP-N-acetylglucosamine transporter TMEM241 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (3) that has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK038472, AK051727, BC094382
    UniProtKB/TrEMBL
    A0A1B0GSM8

  3. NM_178801.5 → NP_848916.2  UDP-N-acetylglucosamine transporter TMEM241 isoform 2

    See identical proteins and their annotated locations for NP_848916.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. This results in a shorter isoform (2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK038472, AK051727, BC094382
    Consensus CDS
    CCDS84359.1
    UniProtKB/TrEMBL
    B2RPV5
    Related
    ENSMUSP00000052001.8, ENSMUST00000055447.14
    Conserved Domains (1) summary
    COG5070
    Location:10 → 193
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RNA

  1. NR_110356.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK031517, AK038472, AK051727
    Related
    ENSMUST00000211298.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    12113193..12254604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526053.5 → XP_006526116.1  transmembrane protein 241 isoform X5

    UniProtKB/TrEMBL
    B2RPV5
    Conserved Domains (1) summary
    COG5070
    Location:122 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  2. XM_006526056.5 → XP_006526119.1  transmembrane protein 241 isoform X8

    UniProtKB/TrEMBL
    B2RPV5
    Conserved Domains (1) summary
    COG5070
    Location:122 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  3. XM_011246964.4 → XP_011245266.1  transmembrane protein 241 isoform X7

    See identical proteins and their annotated locations for XP_011245266.1

    Conserved Domains (1) summary
    COG5070
    Location:104 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  4. XM_006526055.5 → XP_006526118.1  transmembrane protein 241 isoform X7

    See identical proteins and their annotated locations for XP_006526118.1

    Conserved Domains (1) summary
    COG5070
    Location:104 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  5. XM_030250518.2 → XP_030106378.1  transmembrane protein 241 isoform X17

    UniProtKB/TrEMBL
    B2RPV5
    Conserved Domains (1) summary
    COG5070
    Location:10 → 167
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  6. XM_036161196.1 → XP_036017089.1  transmembrane protein 241 isoform X25

    Conserved Domains (1) summary
    COG5070
    Location:10 → 100
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  7. XM_036161192.1 → XP_036017085.1  transmembrane protein 241 isoform X16

    UniProtKB/TrEMBL
    B2RPV5

  8. XM_036161193.1 → XP_036017086.1  transmembrane protein 241 isoform X19

    UniProtKB/TrEMBL
    B2RPV5

  9. XM_030250519.2 → XP_030106379.1  transmembrane protein 241 isoform X22

    Conserved Domains (1) summary
    COG5070
    Location:10 → 193
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  10. XM_036161191.1 → XP_036017084.1  transmembrane protein 241 isoform X13

    UniProtKB/TrEMBL
    B2RPV5

  11. XM_011246967.4 → XP_011245269.1  transmembrane protein 241 isoform X18

    Conserved Domains (1) summary
    COG5070
    Location:104 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  12. XM_036161194.1 → XP_036017087.1  transmembrane protein 241 isoform X21

    UniProtKB/TrEMBL
    B2RPV5
    Conserved Domains (1) summary
    COG5070
    Location:21 → 142
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  13. XM_006526057.5 → XP_006526120.1  transmembrane protein 241 isoform X9

    Conserved Domains (1) summary
    COG5070
    Location:104 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  14. XM_006526059.5 → XP_006526122.1  transmembrane protein 241 isoform X11

    Conserved Domains (1) summary
    COG5070
    Location:104 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  15. XM_006526054.5 → XP_006526117.1  transmembrane protein 241 isoform X6

    Conserved Domains (1) summary
    COG5070
    Location:104 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  16. XM_006526051.5 → XP_006526114.1  transmembrane protein 241 isoform X1

    Conserved Domains (1) summary
    COG5070
    Location:104 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  17. XM_006526052.5 → XP_006526115.1  transmembrane protein 241 isoform X2

    Conserved Domains (1) summary
    COG5070
    Location:104 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  18. XM_006526060.5 → XP_006526123.1  transmembrane protein 241 isoform X14

    Conserved Domains (1) summary
    COG5070
    Location:10 → 167
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  19. XM_006526058.5 → XP_006526121.1  transmembrane protein 241 isoform X10

    Conserved Domains (1) summary
    COG5070
    Location:10 → 193
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  20. XM_036161190.1 → XP_036017083.1  transmembrane protein 241 isoform X4

  21. XM_036161189.1 → XP_036017082.1  transmembrane protein 241 isoform X3

  22. XM_011246966.4 → XP_011245268.1  transmembrane protein 241 isoform X15

    Conserved Domains (1) summary
    COG5070
    Location:21 → 142
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  23. XM_011246965.2 → XP_011245267.1  transmembrane protein 241 isoform X12

    Conserved Domains (1) summary
    COG5070
    Location:53 → 192
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  24. XM_030250520.2 → XP_030106380.1  transmembrane protein 241 isoform X26

    Conserved Domains (1) summary
    COG5070
    Location:10 → 167
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  25. XM_036161195.1 → XP_036017088.1  transmembrane protein 241 isoform X23

    Related
    ENSMUSP00000089709.5, ENSMUST00000092075.5
    Conserved Domains (1) summary
    COG5070
    Location:10 → 193
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  26. XM_006526063.5 → XP_006526126.1  transmembrane protein 241 isoform X20

    Conserved Domains (1) summary
    COG5070
    Location:104 → 243
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  27. XM_011246968.4 → XP_011245270.1  transmembrane protein 241 isoform X24

RNA

  1. XR_003952532.2 RNA Sequence

  2. XR_003952529.2 RNA Sequence

  3. XR_003952530.2 RNA Sequence

  4. XR_004939867.1 RNA Sequence

  5. XR_003952533.2 RNA Sequence

  6. XR_386003.5 RNA Sequence

  7. XR_386002.5 RNA Sequence

  8. XR_386001.5 RNA Sequence

  9. XR_386000.5 RNA Sequence

  10. XR_004939869.1 RNA Sequence

  11. XR_004939868.1 RNA Sequence

  12. XR_004939870.1 RNA Sequence

  13. XR_004939871.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UME2.2 GenPept UniProtKB/Swiss-Prot:Q3UME2

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